Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory
Transcranial magnetic stimulation is a widely used brain intervention technique in clinical settings. In recent years, the role of the cerebellum in learning and memory has become one of the hotspots in the field of cognitive neuroscience. In this study, we recruited 36 healthy college or graduate s...
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MDPI AG
2023-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/8/1158 |
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| author | Jiangnan Yao Bo Song Jingping Shi Kuiying Yin Wentao Du |
| author_facet | Jiangnan Yao Bo Song Jingping Shi Kuiying Yin Wentao Du |
| author_sort | Jiangnan Yao |
| collection | DOAJ |
| description | Transcranial magnetic stimulation is a widely used brain intervention technique in clinical settings. In recent years, the role of the cerebellum in learning and memory has become one of the hotspots in the field of cognitive neuroscience. In this study, we recruited 36 healthy college or graduate students as subjects and divided them into groups, with 10 to 14 subjects in each group. We performed 5 Hz and 20 Hz repeated transcranial magnetic stimulation and sham stimulation on the Crus II subregion of the cerebellum in different groups, then let them complete the 2-back working memory task before and after the stimulation. We simultaneously recorded the electroencephalogram in the experiment and analyzed the data. We found that after repeated transcranial magnetic stimulation of the cerebellum at 5 Hz and 20 Hz, the N170 and P300 event-related potential components in the prefrontal cortex showed significant differences compared to those in the sham stimulation group. Using phase-locked values to construct brain networks and conduct further analysis, we discovered that stimulation frequencies of 5 Hz and 20 Hz had significant effects on the local and global efficiency of brain networks in comparison to the sham stimulation group. The results showed that repeated transcranial magnetic stimulation on cerebellar targets can effectively affect the subjects’ working memory tasks. Repeated transcranial magnetic stimulation at 5 Hz and 20 Hz could enhance the excitatory responses of the frontal lobes. After stimulation at 5 Hz and 20 Hz, the efficiency of the brain network significantly improved. |
| first_indexed | 2024-03-11T00:05:28Z |
| format | Article |
| id | doaj.art-77b7a631e0b84e819069b4822fafc164 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T00:05:28Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-77b7a631e0b84e819069b4822fafc1642023-11-19T00:26:33ZengMDPI AGBrain Sciences2076-34252023-08-01138115810.3390/brainsci13081158Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working MemoryJiangnan Yao0Bo Song1Jingping Shi2Kuiying Yin3Wentao Du4Nanjing Research Institute of Electronic Technology, Nanjing 210019, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaNanjing Research Institute of Electronic Technology, Nanjing 210019, ChinaNanjing Research Institute of Electronic Technology, Nanjing 210019, ChinaTranscranial magnetic stimulation is a widely used brain intervention technique in clinical settings. In recent years, the role of the cerebellum in learning and memory has become one of the hotspots in the field of cognitive neuroscience. In this study, we recruited 36 healthy college or graduate students as subjects and divided them into groups, with 10 to 14 subjects in each group. We performed 5 Hz and 20 Hz repeated transcranial magnetic stimulation and sham stimulation on the Crus II subregion of the cerebellum in different groups, then let them complete the 2-back working memory task before and after the stimulation. We simultaneously recorded the electroencephalogram in the experiment and analyzed the data. We found that after repeated transcranial magnetic stimulation of the cerebellum at 5 Hz and 20 Hz, the N170 and P300 event-related potential components in the prefrontal cortex showed significant differences compared to those in the sham stimulation group. Using phase-locked values to construct brain networks and conduct further analysis, we discovered that stimulation frequencies of 5 Hz and 20 Hz had significant effects on the local and global efficiency of brain networks in comparison to the sham stimulation group. The results showed that repeated transcranial magnetic stimulation on cerebellar targets can effectively affect the subjects’ working memory tasks. Repeated transcranial magnetic stimulation at 5 Hz and 20 Hz could enhance the excitatory responses of the frontal lobes. After stimulation at 5 Hz and 20 Hz, the efficiency of the brain network significantly improved.https://www.mdpi.com/2076-3425/13/8/1158repeated transcranial magnetic stimulation (rTMS)cerebellumworking memory (WM)event-related potentials (ERP)brain network |
| spellingShingle | Jiangnan Yao Bo Song Jingping Shi Kuiying Yin Wentao Du Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory Brain Sciences repeated transcranial magnetic stimulation (rTMS) cerebellum working memory (WM) event-related potentials (ERP) brain network |
| title | Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory |
| title_full | Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory |
| title_fullStr | Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory |
| title_full_unstemmed | Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory |
| title_short | Effects of Repetitive Transcranial Magnetic Stimulation at the Cerebellum on Working Memory |
| title_sort | effects of repetitive transcranial magnetic stimulation at the cerebellum on working memory |
| topic | repeated transcranial magnetic stimulation (rTMS) cerebellum working memory (WM) event-related potentials (ERP) brain network |
| url | https://www.mdpi.com/2076-3425/13/8/1158 |
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