Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement
Abstract Patients with enteral access usually receive oral drugs via feeding tubes and correct drug administration remains a challenge. The aim of this study was to identify common medication delivery errors (MDEs) in outpatients with percutaneous endoscopic gastrostomy (PEG) and evaluate their asso...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Nature Portfolio
2023-12-01
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| Ráidu: | Scientific Reports |
| Liŋkkat: | https://doi.org/10.1038/s41598-023-48629-w |
| _version_ | 1827590633905192960 |
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| author | David García González Ana Martín-Suárez Juan José Salvador Sánchez Jesús Ángel Sánchez Serrano M. Victoria Calvo |
| author_facet | David García González Ana Martín-Suárez Juan José Salvador Sánchez Jesús Ángel Sánchez Serrano M. Victoria Calvo |
| author_sort | David García González |
| collection | DOAJ |
| description | Abstract Patients with enteral access usually receive oral drugs via feeding tubes and correct drug administration remains a challenge. The aim of this study was to identify common medication delivery errors (MDEs) in outpatients with percutaneous endoscopic gastrostomy (PEG) and evaluate their association with the need for tube replacement due to deterioration or clogging. A 2-year retrospective study that comprised adult outpatients with a placed/replaced PEG tube and whose electronic medical record included home medication was carried out. Treatment with medication that should not be crushed and administered through an enteral feeding tube was considered an MDE. We included 269 patients and 213 MDEs (20% of oral prescriptions) were detected in 159. Ninety-two percent of the medications associated with MDEs could be substituted by appropriate formulations. Tube replacement due to obstruction was needed in 85 patients. MDEs were associated with increased risk for tube replacement (OR 2.17; 95% CI 1.10–4.27). Omeprazole enteric-coated capsules were associated with the greatest risk (OR 2.24; 95% CI 1.01–4.93). PEG outpatients are highly exposed to MDEs, leading to a significant increase in the odds of tube replacement, mainly when treated with omeprazole. The use of appropriate alternative therapies would prevent unnecessary adverse events. |
| first_indexed | 2024-03-09T01:19:34Z |
| format | Article |
| id | doaj.art-77b901b9f40e4d749c7f6256e31184af |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T01:19:34Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-77b901b9f40e4d749c7f6256e31184af2023-12-10T12:14:15ZengNature PortfolioScientific Reports2045-23222023-12-011311810.1038/s41598-023-48629-wMedication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacementDavid García González0Ana Martín-Suárez1Juan José Salvador Sánchez2Jesús Ángel Sánchez Serrano3M. Victoria Calvo4Institute for Biomedical Research of Salamanca (IBSAL)Institute for Biomedical Research of Salamanca (IBSAL)Emergency Service, University Hospital of SalamancaEmergency Service, University Hospital of SalamancaInstitute for Biomedical Research of Salamanca (IBSAL)Abstract Patients with enteral access usually receive oral drugs via feeding tubes and correct drug administration remains a challenge. The aim of this study was to identify common medication delivery errors (MDEs) in outpatients with percutaneous endoscopic gastrostomy (PEG) and evaluate their association with the need for tube replacement due to deterioration or clogging. A 2-year retrospective study that comprised adult outpatients with a placed/replaced PEG tube and whose electronic medical record included home medication was carried out. Treatment with medication that should not be crushed and administered through an enteral feeding tube was considered an MDE. We included 269 patients and 213 MDEs (20% of oral prescriptions) were detected in 159. Ninety-two percent of the medications associated with MDEs could be substituted by appropriate formulations. Tube replacement due to obstruction was needed in 85 patients. MDEs were associated with increased risk for tube replacement (OR 2.17; 95% CI 1.10–4.27). Omeprazole enteric-coated capsules were associated with the greatest risk (OR 2.24; 95% CI 1.01–4.93). PEG outpatients are highly exposed to MDEs, leading to a significant increase in the odds of tube replacement, mainly when treated with omeprazole. The use of appropriate alternative therapies would prevent unnecessary adverse events.https://doi.org/10.1038/s41598-023-48629-w |
| spellingShingle | David García González Ana Martín-Suárez Juan José Salvador Sánchez Jesús Ángel Sánchez Serrano M. Victoria Calvo Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement Scientific Reports |
| title | Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement |
| title_full | Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement |
| title_fullStr | Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement |
| title_full_unstemmed | Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement |
| title_short | Medication delivery errors in outpatients with percutaneous endoscopic gastrostomy: effect on tube feeding replacement |
| title_sort | medication delivery errors in outpatients with percutaneous endoscopic gastrostomy effect on tube feeding replacement |
| url | https://doi.org/10.1038/s41598-023-48629-w |
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