Nanocrytals-Mediated Oral Drug Delivery: Enhanced Bioavailability of Amiodarone

Nanocrytals-Mediated Oral Drug Delivery: Enhanced Bioavailability of Amiodarone

The aim of this study was to improve the saturation solubility, dissolution profile and oral bioavailability of amiodarone hydrochloride (AMH), a highly lipophilic drug. Stabilizer (Pluronic F-127)-coated AMH nanocrystals (AMH-NCs) were developed by a combination of antisolvent precipitation and hom...

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Bibliographic Details
Main Authors: Anum Munir Awan, Arshad Farid, Shefaat Ullah Shah, Dildar Khan, Fiza Ur Rehman, Muhammad Junaid Dar, Tayyaba Iftikhar, Shakira Ghazanfar, Charis M. Galanakis, Abdulhakeem S. Alamri, Syed Mohammed Basheeruddin Asdaq, Kifayat Ullah Shah
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
amiodarone HCl
nanocrystals
pluronic F-127
drug delivery
bioavailability enhancement
Online Access:https://www.mdpi.com/1999-4923/14/6/1300

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