MicroRNA function in megakaryocytes
Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK. Megakaryocytopoiesis is controlled by...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-10-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1528343 |
| _version_ | 1797684271871164416 |
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| author | Sanjeev Raghuwanshi Swati Dahariya Syed Shahid Musvi Usha Gutti Ravinder Kandi Ram Babu Undi Itishri Sahu Dushyant Kumar Gautam Indira Paddibhatla Ravi Kumar Gutti |
| author_facet | Sanjeev Raghuwanshi Swati Dahariya Syed Shahid Musvi Usha Gutti Ravinder Kandi Ram Babu Undi Itishri Sahu Dushyant Kumar Gautam Indira Paddibhatla Ravi Kumar Gutti |
| author_sort | Sanjeev Raghuwanshi |
| collection | DOAJ |
| description | Megakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK. Megakaryocytopoiesis is controlled by a complex network of bone marrow niche factors. Traditionally, the studies on megakaryocytopoiesis were focused on different cytokines, growth factors and transcription factors as the regulators of megakaryocytopoiesis. Over the past two decades many research groups have uncovered the key role of microRNAs (miRNAs) in megakaryocytopoiesis. miRNAs are a class of small length non-coding RNAs which play key regulatory role in cellular processes such as proliferation, differentiation and development and are also known to be involved in disease development. This review summarizes the current state of knowledge of miRNAs which have changed expression during megakaryocytopoiesis, also focuses on miRNAs which are differentially regulated during developmental maturation of MKs. Further, we aimed to discuss potential mechanisms of miRNAs-mediated regulation underlying megakaryocytopoiesis and developmental maturation of MKs. |
| first_indexed | 2024-03-12T00:27:06Z |
| format | Article |
| id | doaj.art-77bab6f924bf4bf9b651b4197e4d0ba8 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:06Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-77bab6f924bf4bf9b651b4197e4d0ba82023-09-15T10:32:00ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-10-0130780981610.1080/09537104.2018.15283431528343MicroRNA function in megakaryocytesSanjeev Raghuwanshi0Swati Dahariya1Syed Shahid Musvi2Usha Gutti3Ravinder Kandi4Ram Babu Undi5Itishri Sahu6Dushyant Kumar Gautam7Indira Paddibhatla8Ravi Kumar Gutti9School of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadGITAM Institute of Science, GITAM UniversitySchool of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadSchool of Life Sciences, University of HyderabadMegakaryocytes (MKs), the largest cells in the bone marrow, are generated from hematopoietic stem cells (HSCs) in a sequential process called megakaryocytopoiesis in which HSCs undergo MK-progenitor (MP) commitment and maturation to terminally differentiated MK. Megakaryocytopoiesis is controlled by a complex network of bone marrow niche factors. Traditionally, the studies on megakaryocytopoiesis were focused on different cytokines, growth factors and transcription factors as the regulators of megakaryocytopoiesis. Over the past two decades many research groups have uncovered the key role of microRNAs (miRNAs) in megakaryocytopoiesis. miRNAs are a class of small length non-coding RNAs which play key regulatory role in cellular processes such as proliferation, differentiation and development and are also known to be involved in disease development. This review summarizes the current state of knowledge of miRNAs which have changed expression during megakaryocytopoiesis, also focuses on miRNAs which are differentially regulated during developmental maturation of MKs. Further, we aimed to discuss potential mechanisms of miRNAs-mediated regulation underlying megakaryocytopoiesis and developmental maturation of MKs.http://dx.doi.org/10.1080/09537104.2018.1528343megakaryocytemirna |
| spellingShingle | Sanjeev Raghuwanshi Swati Dahariya Syed Shahid Musvi Usha Gutti Ravinder Kandi Ram Babu Undi Itishri Sahu Dushyant Kumar Gautam Indira Paddibhatla Ravi Kumar Gutti MicroRNA function in megakaryocytes Platelets megakaryocyte mirna |
| title | MicroRNA function in megakaryocytes |
| title_full | MicroRNA function in megakaryocytes |
| title_fullStr | MicroRNA function in megakaryocytes |
| title_full_unstemmed | MicroRNA function in megakaryocytes |
| title_short | MicroRNA function in megakaryocytes |
| title_sort | microrna function in megakaryocytes |
| topic | megakaryocyte mirna |
| url | http://dx.doi.org/10.1080/09537104.2018.1528343 |
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