Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study
Abstract Background Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Journal of Biomedical Science |
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| Online Access: | http://link.springer.com/article/10.1186/s12929-017-0344-x |
| _version_ | 1811266587922006016 |
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| author | Jeyanthi Suppiah Shie-Yien Chan Min-Wern Ng Yam-Sim Khaw Siew-Mooi Ching Lailatul Akmar Mat-Nor Naematul Ain Ahmad-Najimudin Hui-Yee Chee |
| author_facet | Jeyanthi Suppiah Shie-Yien Chan Min-Wern Ng Yam-Sim Khaw Siew-Mooi Ching Lailatul Akmar Mat-Nor Naematul Ain Ahmad-Najimudin Hui-Yee Chee |
| author_sort | Jeyanthi Suppiah |
| collection | DOAJ |
| description | Abstract Background Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection. Method Two hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction. Clinical, laboratory and demographic data were extracted from the hospital database to identify patients with confirmed leptospirosis infection among the dengue patients. Thus, frequency of co-infection was calculated and association of the dataset with dengue-leptospirosis co-infection was statistically determined. Results The frequency of dengue co-infection with leptospirosis was 4.1%. Male has higher preponderance of developing the co-infection and end result of shock as clinical symptom is more likely present among co-infected cases. It is also noteworthy that, DENV 1 is the common dengue serotype among all cases identified as dengue-leptospirosis co-infection in this study. Conclusion The increasing incidence of leptospirosis among dengue infected patients has posed the need to precisely identify the presence of co-infection for the betterment of treatment without mistakenly ruling out either one of them. Thus, anticipating the possible clinical symptoms and laboratory results of dengue-leptospirosis co-infection is essential. |
| first_indexed | 2024-04-12T20:44:58Z |
| format | Article |
| id | doaj.art-77bc025b77754c8ba506d0adbde75256 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-04-12T20:44:58Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-77bc025b77754c8ba506d0adbde752562022-12-22T03:17:17ZengBMCJournal of Biomedical Science1423-01272017-06-012411810.1186/s12929-017-0344-xClinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot studyJeyanthi Suppiah0Shie-Yien Chan1Min-Wern Ng2Yam-Sim Khaw3Siew-Mooi Ching4Lailatul Akmar Mat-Nor5Naematul Ain Ahmad-Najimudin6Hui-Yee Chee7Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaMicrobiology Unit, Department of Pathology, Hospital SerdangMicrobiology Unit, Department of Pathology, Hospital SerdangDepartment of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra MalaysiaAbstract Background Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. As a solution, the present work initiated a pilot study to investigate the incidence related to co-infection of leptospirosis among dengue patients. This enables the identification of more parameters to predict the occurrence of co-infection. Method Two hundred sixty eight serum specimens collected from patients that were diagnosed for dengue fever were confirmed for dengue virus serotyping by real-time polymerase chain reaction. Clinical, laboratory and demographic data were extracted from the hospital database to identify patients with confirmed leptospirosis infection among the dengue patients. Thus, frequency of co-infection was calculated and association of the dataset with dengue-leptospirosis co-infection was statistically determined. Results The frequency of dengue co-infection with leptospirosis was 4.1%. Male has higher preponderance of developing the co-infection and end result of shock as clinical symptom is more likely present among co-infected cases. It is also noteworthy that, DENV 1 is the common dengue serotype among all cases identified as dengue-leptospirosis co-infection in this study. Conclusion The increasing incidence of leptospirosis among dengue infected patients has posed the need to precisely identify the presence of co-infection for the betterment of treatment without mistakenly ruling out either one of them. Thus, anticipating the possible clinical symptoms and laboratory results of dengue-leptospirosis co-infection is essential.http://link.springer.com/article/10.1186/s12929-017-0344-xDengue feverLeptospirosisCo-infectionShockSerotypeMalaysia |
| spellingShingle | Jeyanthi Suppiah Shie-Yien Chan Min-Wern Ng Yam-Sim Khaw Siew-Mooi Ching Lailatul Akmar Mat-Nor Naematul Ain Ahmad-Najimudin Hui-Yee Chee Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study Journal of Biomedical Science Dengue fever Leptospirosis Co-infection Shock Serotype Malaysia |
| title | Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study |
| title_full | Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study |
| title_fullStr | Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study |
| title_full_unstemmed | Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study |
| title_short | Clinical predictors of dengue fever co-infected with leptospirosis among patients admitted for dengue fever – a pilot study |
| title_sort | clinical predictors of dengue fever co infected with leptospirosis among patients admitted for dengue fever a pilot study |
| topic | Dengue fever Leptospirosis Co-infection Shock Serotype Malaysia |
| url | http://link.springer.com/article/10.1186/s12929-017-0344-x |
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