Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study

Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study

Abstract Introduction Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germline mutation have been describe in Caucasian populations. The aim...

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Main Authors: Milena Casula, Panagiotis Paliogiannis, Fabrizio Ayala, Vincenzo De Giorgi, Ignazio Stanganelli, Mario Mandalà, Maria Colombino, Antonella Manca, Maria Cristina Sini, Corrado Caracò, Paolo Antonio Ascierto, Rosanna Rita Satta, Melanoma Unit of Sassari (MUS), Amelia Lissia, Antonio Cossu, Giuseppe Palmieri, for the Italian Melanoma Intergroup (IMI)
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Skin
Cancer
Melanoma
Mutations
NGS
CDKN2A
Online Access:http://link.springer.com/article/10.1186/s12885-019-5984-7

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