Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria
The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00692/full |
| _version_ | 1818335944874393600 |
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| author | Renata Lima Fernando Sá Del Fiol Victor M. Balcão Victor M. Balcão |
| author_facet | Renata Lima Fernando Sá Del Fiol Victor M. Balcão Victor M. Balcão |
| author_sort | Renata Lima |
| collection | DOAJ |
| description | The increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistant to the antibiotics currently available, as well as to the selective development of other microorganisms, hence contributing to the widespread dissemination of resistance genes at the environmental level. Due to this, attempts are being made to develop new techniques to combat resistant bacteria, among them the use of strictly lytic bacteriophage particles, CRISPR–Cas, and nanotechnology. The use of these technologies, alone or in combination, is promising for solving a problem that humanity faces today and that could lead to human extinction: the domination of pathogenic bacteria resistant to artificial drugs. This prospective paper discusses the potential of bacteriophage particles, CRISPR–Cas, and nanotechnology for use in combating human (bacterial) infections. |
| first_indexed | 2024-12-13T14:31:29Z |
| format | Article |
| id | doaj.art-77c191dfb9b9436f8a9161f7513d081c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T14:31:29Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-77c191dfb9b9436f8a9161f7513d081c2022-12-21T23:41:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-06-011010.3389/fphar.2019.00692443600Prospects for the Use of New Technologies to Combat Multidrug-Resistant BacteriaRenata Lima0Fernando Sá Del Fiol1Victor M. Balcão2Victor M. Balcão3LABiToN—Laboratory of Bioactivity Assessment and Toxicology of Nanomaterials, University of Sorocaba, Sorocaba, BrazilCRIA—Antibiotic Reference and Information Center, University of Sorocaba, Sorocaba, BrazilPhageLab—Laboratory of Biofilms and Bacteriophages, i(bs)2—intelligent biosensing and biomolecule stabilization research group, University of Sorocaba, Sorocaba, BrazilDepartment of Biology and CESAM, University of Aveiro, Campus Universitário de Santiago, Aveiro, PortugalThe increasing use of antibiotics is being driven by factors such as the aging of the population, increased occurrence of infections, and greater prevalence of chronic diseases that require antimicrobial treatment. The excessive and unnecessary use of antibiotics in humans has led to the emergence of bacteria resistant to the antibiotics currently available, as well as to the selective development of other microorganisms, hence contributing to the widespread dissemination of resistance genes at the environmental level. Due to this, attempts are being made to develop new techniques to combat resistant bacteria, among them the use of strictly lytic bacteriophage particles, CRISPR–Cas, and nanotechnology. The use of these technologies, alone or in combination, is promising for solving a problem that humanity faces today and that could lead to human extinction: the domination of pathogenic bacteria resistant to artificial drugs. This prospective paper discusses the potential of bacteriophage particles, CRISPR–Cas, and nanotechnology for use in combating human (bacterial) infections.https://www.frontiersin.org/article/10.3389/fphar.2019.00692/fullmultidrug-resistant bacteriabacteriophage particlesphage therapyCRISPR–Casnanotechnology |
| spellingShingle | Renata Lima Fernando Sá Del Fiol Victor M. Balcão Victor M. Balcão Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria Frontiers in Pharmacology multidrug-resistant bacteria bacteriophage particles phage therapy CRISPR–Cas nanotechnology |
| title | Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria |
| title_full | Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria |
| title_fullStr | Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria |
| title_full_unstemmed | Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria |
| title_short | Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria |
| title_sort | prospects for the use of new technologies to combat multidrug resistant bacteria |
| topic | multidrug-resistant bacteria bacteriophage particles phage therapy CRISPR–Cas nanotechnology |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00692/full |
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