Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation
(1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA<sub>2</sub>DS<sub>2</sub>-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RF...
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/11/3111 |
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| author | Do Young Kim Yun Gi Kim Ha Young Choi Yun Young Choi Ki Yung Boo Kwang-No Lee Seung-Young Roh Jaemin Shim Jong-Il Choi Young-Hoon Kim |
| author_facet | Do Young Kim Yun Gi Kim Ha Young Choi Yun Young Choi Ki Yung Boo Kwang-No Lee Seung-Young Roh Jaemin Shim Jong-Il Choi Young-Hoon Kim |
| author_sort | Do Young Kim |
| collection | DOAJ |
| description | (1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA<sub>2</sub>DS<sub>2</sub>-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were defined as regions with bipolar peak-to-peak voltages of <0.5 mV. The proportion of LVAs was calculated by dividing the total LVA by the LA surface area. (3) Results: There was no sex-related difference in LA LVAs among patients with a CHA<sub>2</sub>DS<sub>2</sub>-VA scores ≤ 2. The proportion of LVAs was significantly higher in females among patients with CHA<sub>2</sub>DS<sub>2</sub>-VA scores of 3 or 4 (10.1 (4.7–15.1)% vs. 15.8 (9.2–32.1)%; <i>p</i> = 0.027). Female sex was significantly associated with extensive LVAs (LVA proportion ≥ 30%). Females had odd ratios of 27.82 (95% confidence interval (CI) 3.33–756.8, <i>p</i> = 0.01), and 1.53 (95% CI 0.81–2.83, <i>p</i> = 0.184) for extensive LAVs in patients with CHA<sub>2</sub>DS<sub>2</sub>-VA scores ≥ 3 and CHA<sub>2</sub>DS<sub>2</sub>-VA scores < 3, respectively. In the multiple regression model, female patients with a CHA<sub>2</sub>DS<sub>2</sub>-VA ≥3 were significantly associated with a higher proportion of LVAs (β = 8.52, <i>p</i> = 0.039). (4) Conclusions: Female sex was significantly associated with extensive LVAs, particularly when their CHA<sub>2</sub>DS<sub>2</sub>-VA scores were ≥3. This result suggests that female sex has a differential effect on the extent of LVAs based on the presence of additional risk factors. |
| first_indexed | 2024-03-10T01:11:21Z |
| format | Article |
| id | doaj.art-77c4e4139f1148fe89a58fd158b08824 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:11:21Z |
| publishDate | 2022-05-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-77c4e4139f1148fe89a58fd158b088242023-11-23T14:17:00ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011111311110.3390/jcm11113111Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial FibrillationDo Young Kim0Yun Gi Kim1Ha Young Choi2Yun Young Choi3Ki Yung Boo4Kwang-No Lee5Seung-Young Roh6Jaemin Shim7Jong-Il Choi8Young-Hoon Kim9Division of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, KoreaDivision of Cardiology, Soonchunhyang University Chonan Hospital, Chonan 31151, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, KoreaDivision of Cardiology, Jeju National University Hospital, Jeju 63241, KoreaDepartment of Cardiology, Ajou University School of Medicine, Suwon 16499, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, KoreaDivision of Cardiology, Department of Internal Medicine, Korea University Medical Center, Seoul 02841, Korea(1) Background: We hypothesized that female sex would have a differential impact on left atrial (LA) low-voltage areas (LVAs) according to CHA<sub>2</sub>DS<sub>2</sub>-VA scores. (2) Methods: This study included 553 patients who underwent radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). LVAs were defined as regions with bipolar peak-to-peak voltages of <0.5 mV. The proportion of LVAs was calculated by dividing the total LVA by the LA surface area. (3) Results: There was no sex-related difference in LA LVAs among patients with a CHA<sub>2</sub>DS<sub>2</sub>-VA scores ≤ 2. The proportion of LVAs was significantly higher in females among patients with CHA<sub>2</sub>DS<sub>2</sub>-VA scores of 3 or 4 (10.1 (4.7–15.1)% vs. 15.8 (9.2–32.1)%; <i>p</i> = 0.027). Female sex was significantly associated with extensive LVAs (LVA proportion ≥ 30%). Females had odd ratios of 27.82 (95% confidence interval (CI) 3.33–756.8, <i>p</i> = 0.01), and 1.53 (95% CI 0.81–2.83, <i>p</i> = 0.184) for extensive LAVs in patients with CHA<sub>2</sub>DS<sub>2</sub>-VA scores ≥ 3 and CHA<sub>2</sub>DS<sub>2</sub>-VA scores < 3, respectively. In the multiple regression model, female patients with a CHA<sub>2</sub>DS<sub>2</sub>-VA ≥3 were significantly associated with a higher proportion of LVAs (β = 8.52, <i>p</i> = 0.039). (4) Conclusions: Female sex was significantly associated with extensive LVAs, particularly when their CHA<sub>2</sub>DS<sub>2</sub>-VA scores were ≥3. This result suggests that female sex has a differential effect on the extent of LVAs based on the presence of additional risk factors.https://www.mdpi.com/2077-0383/11/11/3111atrial fibrillationcatheter ablationfemalesexelectro-anatomical remodelinglow voltage area |
| spellingShingle | Do Young Kim Yun Gi Kim Ha Young Choi Yun Young Choi Ki Yung Boo Kwang-No Lee Seung-Young Roh Jaemin Shim Jong-Il Choi Young-Hoon Kim Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation Journal of Clinical Medicine atrial fibrillation catheter ablation female sex electro-anatomical remodeling low voltage area |
| title | Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation |
| title_full | Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation |
| title_fullStr | Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation |
| title_full_unstemmed | Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation |
| title_short | Sex-Related Differences in Left Atrial Low-Voltage Areas According to CHA<sub>2</sub>DS<sub>2</sub>-VA Scores among Patients with Atrial Fibrillation |
| title_sort | sex related differences in left atrial low voltage areas according to cha sub 2 sub ds sub 2 sub va scores among patients with atrial fibrillation |
| topic | atrial fibrillation catheter ablation female sex electro-anatomical remodeling low voltage area |
| url | https://www.mdpi.com/2077-0383/11/11/3111 |
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