A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine
A disposable screen-printed carbon electrode (SPCE) modified with chemically reduced graphene oxide (rGO) (rGO-SPCE) is described. The rGO-SPCE was characterized by UV-Vis and electrochemical impedance spectroscopy, and cyclic voltammetry. The electrode displays excellent electrocatalytic activity t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-12-01
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| Series: | Chemosensors |
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| Online Access: | http://www.mdpi.com/2227-9040/4/4/25 |
| _version_ | 1811294069238792192 |
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| author | Prosper Kanyong Sean Rawlinson James Davis |
| author_facet | Prosper Kanyong Sean Rawlinson James Davis |
| author_sort | Prosper Kanyong |
| collection | DOAJ |
| description | A disposable screen-printed carbon electrode (SPCE) modified with chemically reduced graphene oxide (rGO) (rGO-SPCE) is described. The rGO-SPCE was characterized by UV-Vis and electrochemical impedance spectroscopy, and cyclic voltammetry. The electrode displays excellent electrocatalytic activity towards uric acid (UA), ascorbic acid (AA) and dopamine (DA). Three resolved voltammetric peaks (at 183 mV for UA, 273 mV for AA and 317 mV for DA, all vs. Ag/AgCl) were found. Differential pulse voltammetry was used to simultaneously detect UA, AA and DA in their ternary mixtures. The linear working range extends from 10 to 3000 μM for UA; 0.1 to 2.5 μM, and 5.0 to 2 × 104 µM for AA; and 0.2 to 80.0 μM and 120.0 to 500 µM for DA, and the limits of detection (S/N = 3) are 0.1, 50.0, and 0.4 μM, respectively. The performance of the sensor was evaluated by analysing spiked human urine samples, and the recoveries were found to be well over 98.0% for the three compounds. These results indicate that the rGO-SPCE represents a sensitive analytical sensing tool for simultaneous analysis of UA, AA and DA. |
| first_indexed | 2024-04-13T05:10:55Z |
| format | Article |
| id | doaj.art-77c4fd9194784458820b1c4a1c94684c |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-04-13T05:10:55Z |
| publishDate | 2016-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-77c4fd9194784458820b1c4a1c94684c2022-12-22T03:01:01ZengMDPI AGChemosensors2227-90402016-12-01442510.3390/chemosensors4040025chemosensors4040025A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and DopamineProsper Kanyong0Sean Rawlinson1James Davis2School of Engineering, Ulster University, Jordanstown BT37 0QB, United KingdomSchool of Engineering, Ulster University, Jordanstown BT37 0QB, United KingdomSchool of Engineering, Ulster University, Jordanstown BT37 0QB, United KingdomA disposable screen-printed carbon electrode (SPCE) modified with chemically reduced graphene oxide (rGO) (rGO-SPCE) is described. The rGO-SPCE was characterized by UV-Vis and electrochemical impedance spectroscopy, and cyclic voltammetry. The electrode displays excellent electrocatalytic activity towards uric acid (UA), ascorbic acid (AA) and dopamine (DA). Three resolved voltammetric peaks (at 183 mV for UA, 273 mV for AA and 317 mV for DA, all vs. Ag/AgCl) were found. Differential pulse voltammetry was used to simultaneously detect UA, AA and DA in their ternary mixtures. The linear working range extends from 10 to 3000 μM for UA; 0.1 to 2.5 μM, and 5.0 to 2 × 104 µM for AA; and 0.2 to 80.0 μM and 120.0 to 500 µM for DA, and the limits of detection (S/N = 3) are 0.1, 50.0, and 0.4 μM, respectively. The performance of the sensor was evaluated by analysing spiked human urine samples, and the recoveries were found to be well over 98.0% for the three compounds. These results indicate that the rGO-SPCE represents a sensitive analytical sensing tool for simultaneous analysis of UA, AA and DA.http://www.mdpi.com/2227-9040/4/4/25multiplex sensinggraphene-based electrodesdifferential pulse voltammetryelectrochemical impedance spectroscopyUV-Vis spectroscopyscreen-printed electrodes |
| spellingShingle | Prosper Kanyong Sean Rawlinson James Davis A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine Chemosensors multiplex sensing graphene-based electrodes differential pulse voltammetry electrochemical impedance spectroscopy UV-Vis spectroscopy screen-printed electrodes |
| title | A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine |
| title_full | A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine |
| title_fullStr | A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine |
| title_full_unstemmed | A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine |
| title_short | A Voltammetric Sensor Based on Chemically Reduced Graphene Oxide-Modified Screen-Printed Carbon Electrode for the Simultaneous Analysis of Uric Acid, Ascorbic Acid and Dopamine |
| title_sort | voltammetric sensor based on chemically reduced graphene oxide modified screen printed carbon electrode for the simultaneous analysis of uric acid ascorbic acid and dopamine |
| topic | multiplex sensing graphene-based electrodes differential pulse voltammetry electrochemical impedance spectroscopy UV-Vis spectroscopy screen-printed electrodes |
| url | http://www.mdpi.com/2227-9040/4/4/25 |
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