Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations
This study aims to compare the efficacy of antiseptic dressings, hyperbaric oxygen therapy, and recombinant human platelet derived growth factor (rhPDGF) for two reasons: i) to reduce the incidence of lower limb amputations in diabetic foot ulcer; ii) to limit the duration of stay in the hospital. A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-02-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.clinicsandpractice.org/index.php/cp/article/view/558 |
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| author | Poras Chaudhary Sachin Khandelwal Dev Datta Poddar Neeraj Saxena Rana A.K. Singh Upendra C. Biswal |
| author_facet | Poras Chaudhary Sachin Khandelwal Dev Datta Poddar Neeraj Saxena Rana A.K. Singh Upendra C. Biswal |
| author_sort | Poras Chaudhary |
| collection | DOAJ |
| description | This study aims to compare the efficacy of antiseptic dressings, hyperbaric oxygen therapy, and recombinant human platelet derived growth factor (rhPDGF) for two reasons: i) to reduce the incidence of lower limb amputations in diabetic foot ulcer; ii) to limit the duration of stay in the hospital. A prospective randomized trial was conducted on 60 patients with stage III and IV diabetic foot ulcers (International Association of Enterostomal Therapy classification) and patients were divided randomly in three different therapy groups - antiseptics, hyperbaric oxygen therapy, recombinant platelet derived growth factor, with 20 patients in each group. Patients were managed initially on inpatient and then on outpatient basis till the ulcer healed completely. Results among three groups were compared using unpaired T test and the level of significance was set at P<0.05 using ANOVA. This study compares the efficacy of hyperbaric oxygen therapy, antiseptic dressings, and rhPDGF in grade III and IV diabetic foot ulcers. P value (0.0348) was significant for complete wound contraction while p value healing time (0.6534) and ulcer size (0.0593) in the groups was not significant. PDGF is safe, effective and easy to apply. Results are comparable with hyperbaric oxygen (HBO) therapy and cost of treatment is lower than other therapies. Diabetic foot ulcer management requires multidisciplinary and aggressive approach. PDGF should be recommended for all grade III and IV diabetic foot ulcer at least 8 weeks old. HBO is equally good an option but has limitations and side effects. |
| first_indexed | 2024-04-11T13:48:30Z |
| format | Article |
| id | doaj.art-77c78aed60414b378b97d9ba62c532d0 |
| institution | Directory Open Access Journal |
| issn | 2039-7275 2039-7283 |
| language | English |
| last_indexed | 2024-04-11T13:48:30Z |
| publishDate | 2013-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-77c78aed60414b378b97d9ba62c532d02022-12-22T04:20:49ZengMDPI AGClinics and Practice2039-72752039-72832013-02-013110.4081/cp.2013.e9234Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputationsPoras Chaudhary0Sachin Khandelwal1Dev Datta Poddar2Neeraj Saxena3Rana A.K. Singh4Upendra C. Biswal5Dr Ram Manohar Lohia Hospital and PGIMER, New DelhiDr Ram Manohar Lohia Hospital and PGIMER, New DelhiDr Ram Manohar Lohia Hospital and PGIMER, New DelhiDr Ram Manohar Lohia Hospital and PGIMER, New DelhiDr Ram Manohar Lohia Hospital and PGIMER, New DelhiDr Ram Manohar Lohia Hospital and PGIMER, New DelhiThis study aims to compare the efficacy of antiseptic dressings, hyperbaric oxygen therapy, and recombinant human platelet derived growth factor (rhPDGF) for two reasons: i) to reduce the incidence of lower limb amputations in diabetic foot ulcer; ii) to limit the duration of stay in the hospital. A prospective randomized trial was conducted on 60 patients with stage III and IV diabetic foot ulcers (International Association of Enterostomal Therapy classification) and patients were divided randomly in three different therapy groups - antiseptics, hyperbaric oxygen therapy, recombinant platelet derived growth factor, with 20 patients in each group. Patients were managed initially on inpatient and then on outpatient basis till the ulcer healed completely. Results among three groups were compared using unpaired T test and the level of significance was set at P<0.05 using ANOVA. This study compares the efficacy of hyperbaric oxygen therapy, antiseptic dressings, and rhPDGF in grade III and IV diabetic foot ulcers. P value (0.0348) was significant for complete wound contraction while p value healing time (0.6534) and ulcer size (0.0593) in the groups was not significant. PDGF is safe, effective and easy to apply. Results are comparable with hyperbaric oxygen (HBO) therapy and cost of treatment is lower than other therapies. Diabetic foot ulcer management requires multidisciplinary and aggressive approach. PDGF should be recommended for all grade III and IV diabetic foot ulcer at least 8 weeks old. HBO is equally good an option but has limitations and side effects.https://www.clinicsandpractice.org/index.php/cp/article/view/558diabetic foot ulcersantiseptic dressinghyperbaric oxygen therapyplatelet derived growth factor gel. |
| spellingShingle | Poras Chaudhary Sachin Khandelwal Dev Datta Poddar Neeraj Saxena Rana A.K. Singh Upendra C. Biswal Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations Clinics and Practice diabetic foot ulcers antiseptic dressing hyperbaric oxygen therapy platelet derived growth factor gel. |
| title | Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations |
| title_full | Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations |
| title_fullStr | Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations |
| title_full_unstemmed | Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations |
| title_short | Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations |
| title_sort | comparative study of different treatment options of grade iii and iv diabetic foot ulcers to reduce the incidence of amputations |
| topic | diabetic foot ulcers antiseptic dressing hyperbaric oxygen therapy platelet derived growth factor gel. |
| url | https://www.clinicsandpractice.org/index.php/cp/article/view/558 |
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