Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites
Abstract Metabolomics has been attracting attention in recent years as an objective method for diagnosing schizophrenia. In this study, we analyzed 378 metabolites in the serum of schizophrenia patients using capillary electrophoresis‐ and liquid chromatography‐time‐of‐flight mass spectrometry. Usin...
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Format: | Article |
Language: | English |
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Wiley
2022-03-01
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Series: | Neuropsychopharmacology Reports |
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Online Access: | https://doi.org/10.1002/npr2.12223 |
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author | Saehyeon Kim Satoshi Okazaki Ikuo Otsuka Yutaka Shinko Tadasu Horai Naofumi Shimmyo Takashi Hirata Naruhisa Yamaki Takaki Tanifuji Shuken Boku Ichiro Sora Akitoyo Hishimoto |
author_facet | Saehyeon Kim Satoshi Okazaki Ikuo Otsuka Yutaka Shinko Tadasu Horai Naofumi Shimmyo Takashi Hirata Naruhisa Yamaki Takaki Tanifuji Shuken Boku Ichiro Sora Akitoyo Hishimoto |
author_sort | Saehyeon Kim |
collection | DOAJ |
description | Abstract Metabolomics has been attracting attention in recent years as an objective method for diagnosing schizophrenia. In this study, we analyzed 378 metabolites in the serum of schizophrenia patients using capillary electrophoresis‐ and liquid chromatography‐time‐of‐flight mass spectrometry. Using multivariate analysis with the orthogonal partial least squares method, we observed significantly higher levels of alanine, glutamate, lactic acid, ornithine, and serine and significantly lower levels of urea, in patients with chronic schizophrenia compared to healthy controls. Additionally, levels of fatty acids (15:0), (17:0), and (19:1), cis‐11‐eicosenoic acid, and thyroxine were significantly higher in patients with acute psychosis than in those in remission. Moreover, we conducted a systematic review of comprehensive metabolomics studies on schizophrenia over the last 20 years and observed consistent trends of increase in some metabolites such as glutamate and glucose, and decrease in citrate in schizophrenia patients across several studies. Hence, we provide substantial evidence for metabolic biomarkers in schizophrenia patients through our metabolomics study. |
first_indexed | 2024-04-11T06:10:55Z |
format | Article |
id | doaj.art-77c7a8001d2148dd867de5ebda0a7fab |
institution | Directory Open Access Journal |
issn | 2574-173X |
language | English |
last_indexed | 2024-04-11T06:10:55Z |
publishDate | 2022-03-01 |
publisher | Wiley |
record_format | Article |
series | Neuropsychopharmacology Reports |
spelling | doaj.art-77c7a8001d2148dd867de5ebda0a7fab2022-12-22T04:41:16ZengWileyNeuropsychopharmacology Reports2574-173X2022-03-01421425110.1002/npr2.12223Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolitesSaehyeon Kim0Satoshi Okazaki1Ikuo Otsuka2Yutaka Shinko3Tadasu Horai4Naofumi Shimmyo5Takashi Hirata6Naruhisa Yamaki7Takaki Tanifuji8Shuken Boku9Ichiro Sora10Akitoyo Hishimoto11Department of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanDepartment of Psychiatry Kobe University Graduate School of Medicine Kobe JapanAbstract Metabolomics has been attracting attention in recent years as an objective method for diagnosing schizophrenia. In this study, we analyzed 378 metabolites in the serum of schizophrenia patients using capillary electrophoresis‐ and liquid chromatography‐time‐of‐flight mass spectrometry. Using multivariate analysis with the orthogonal partial least squares method, we observed significantly higher levels of alanine, glutamate, lactic acid, ornithine, and serine and significantly lower levels of urea, in patients with chronic schizophrenia compared to healthy controls. Additionally, levels of fatty acids (15:0), (17:0), and (19:1), cis‐11‐eicosenoic acid, and thyroxine were significantly higher in patients with acute psychosis than in those in remission. Moreover, we conducted a systematic review of comprehensive metabolomics studies on schizophrenia over the last 20 years and observed consistent trends of increase in some metabolites such as glutamate and glucose, and decrease in citrate in schizophrenia patients across several studies. Hence, we provide substantial evidence for metabolic biomarkers in schizophrenia patients through our metabolomics study.https://doi.org/10.1002/npr2.12223biomarkersmetabolomicspsychosisschizophreniasystematic review |
spellingShingle | Saehyeon Kim Satoshi Okazaki Ikuo Otsuka Yutaka Shinko Tadasu Horai Naofumi Shimmyo Takashi Hirata Naruhisa Yamaki Takaki Tanifuji Shuken Boku Ichiro Sora Akitoyo Hishimoto Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites Neuropsychopharmacology Reports biomarkers metabolomics psychosis schizophrenia systematic review |
title | Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites |
title_full | Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites |
title_fullStr | Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites |
title_full_unstemmed | Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites |
title_short | Searching for biomarkers in schizophrenia and psychosis: Case‐control study using capillary electrophoresis and liquid chromatography time‐of‐flight mass spectrometry and systematic review for biofluid metabolites |
title_sort | searching for biomarkers in schizophrenia and psychosis case control study using capillary electrophoresis and liquid chromatography time of flight mass spectrometry and systematic review for biofluid metabolites |
topic | biomarkers metabolomics psychosis schizophrenia systematic review |
url | https://doi.org/10.1002/npr2.12223 |
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