Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis
(1) Background: Milk fat globule membrane (MFGM), composing fat droplets responsible for lipid transport in breast milk, has been shown to possess immunological and antimicrobial effects. Standard formulas (SF) are devoid of MFGMs during the production process. The study’s aim was to evaluate the sa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/3/714 |
| _version_ | 1797395438993670144 |
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| author | Dominika Ambrożej Karolina Dumycz Piotr Dziechciarz Marek Ruszczyński |
| author_facet | Dominika Ambrożej Karolina Dumycz Piotr Dziechciarz Marek Ruszczyński |
| author_sort | Dominika Ambrożej |
| collection | DOAJ |
| description | (1) Background: Milk fat globule membrane (MFGM), composing fat droplets responsible for lipid transport in breast milk, has been shown to possess immunological and antimicrobial effects. Standard formulas (SF) are devoid of MFGMs during the production process. The study’s aim was to evaluate the safety and benefits of MFGMs supplementation in children. (2) Methods: We searched four databases for randomized controlled trials evaluating the supplementation of MFGMs in children. Growth parameters were chosen as the primary outcome. (3) Results: Twenty-four publications of seventeen studies were included. Meta-analyses assessing the primary outcomes at the age of 4 months included four studies (814 children) comparing the MFGM-supplemented formulas and SF, and two trials (549 children) comparing the MFGM-supplemented formulas and breastfeeding. The primary outcomes were non-inferior in all the experimental MFGM formulas compared to SF, or even represented more similar results to breastfed infants. The promising effects, including a lower incidence of acute otitis media and improved cognitive development, cannot be firmly confirmed due to the small amount of existing evidence. No significant adverse effects were reported in any of the assessed products. (4) Conclusions: The available data signaled beneficial effects and a good safety profile, requiring future research with well-designed trials. |
| first_indexed | 2024-03-09T00:34:36Z |
| format | Article |
| id | doaj.art-77c7b6446f6344c09c6ee769a896eada |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T00:34:36Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-77c7b6446f6344c09c6ee769a896eada2023-12-11T18:15:14ZengMDPI AGNutrients2072-66432021-02-0113371410.3390/nu13030714Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-AnalysisDominika Ambrożej0Karolina Dumycz1Piotr Dziechciarz2Marek Ruszczyński3Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pediatric Pneumonology and Allergy, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pediatrics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pediatrics, Medical University of Warsaw, 02-091 Warsaw, Poland(1) Background: Milk fat globule membrane (MFGM), composing fat droplets responsible for lipid transport in breast milk, has been shown to possess immunological and antimicrobial effects. Standard formulas (SF) are devoid of MFGMs during the production process. The study’s aim was to evaluate the safety and benefits of MFGMs supplementation in children. (2) Methods: We searched four databases for randomized controlled trials evaluating the supplementation of MFGMs in children. Growth parameters were chosen as the primary outcome. (3) Results: Twenty-four publications of seventeen studies were included. Meta-analyses assessing the primary outcomes at the age of 4 months included four studies (814 children) comparing the MFGM-supplemented formulas and SF, and two trials (549 children) comparing the MFGM-supplemented formulas and breastfeeding. The primary outcomes were non-inferior in all the experimental MFGM formulas compared to SF, or even represented more similar results to breastfed infants. The promising effects, including a lower incidence of acute otitis media and improved cognitive development, cannot be firmly confirmed due to the small amount of existing evidence. No significant adverse effects were reported in any of the assessed products. (4) Conclusions: The available data signaled beneficial effects and a good safety profile, requiring future research with well-designed trials.https://www.mdpi.com/2072-6643/13/3/714milk fat globule membraneMFGMfeedinginfant formulachildren |
| spellingShingle | Dominika Ambrożej Karolina Dumycz Piotr Dziechciarz Marek Ruszczyński Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis Nutrients milk fat globule membrane MFGM feeding infant formula children |
| title | Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis |
| title_full | Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis |
| title_fullStr | Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis |
| title_full_unstemmed | Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis |
| title_short | Milk Fat Globule Membrane Supplementation in Children: Systematic Review with Meta-Analysis |
| title_sort | milk fat globule membrane supplementation in children systematic review with meta analysis |
| topic | milk fat globule membrane MFGM feeding infant formula children |
| url | https://www.mdpi.com/2072-6643/13/3/714 |
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