Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum
Pick’s disease (PiD) is a devastating neurodegenerative disease that is characterized by dementia, frontotemporal lobar degeneration, and the aggregation of 3R tau in pathognomonic inclusions known as Pick bodies. The term PiD has adopted many meanings since its conception in 1926, but it is current...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/6/1646 |
| _version_ | 1797595963809857536 |
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| author | Nicole Tamvaka Sireesha Manne Naveen Kondru Owen A. Ross |
| author_facet | Nicole Tamvaka Sireesha Manne Naveen Kondru Owen A. Ross |
| author_sort | Nicole Tamvaka |
| collection | DOAJ |
| description | Pick’s disease (PiD) is a devastating neurodegenerative disease that is characterized by dementia, frontotemporal lobar degeneration, and the aggregation of 3R tau in pathognomonic inclusions known as Pick bodies. The term PiD has adopted many meanings since its conception in 1926, but it is currently used as a strictly neuropathological term, since PiD patients cannot be diagnosed during life. Due to its rarity, PiD remains significantly understudied, and subsequently, the etiology and pathomechanisms of the disease remain to be elucidated. The study of PiD and the preferential 3R tau accumulation that is unique to PiD is imperative in order to expand the current understanding of the disease and inform future studies and therapeutic development, since the lack of intervention strategies for tauopathies remains an unmet need. Yet, the lack of an antemortem diagnostic test for the disease has further complicated the study of PiD. The development of a clinical diagnostic assay for PiD will be a vital step in the study of the disease that will greatly contribute to therapeutic research, clinical trial design and patient recruitment and ultimately improve patient outcomes. Seed aggregation assays have shown great promise for becoming ante mortem clinical diagnostic tools for many proteinopathies, including tauopathies. Future research on adapting and optimizing current seed aggregation assays to successfully detect 3R tau pathogenic forms from PiD samples will be critical in establishing a 3R tau specific seed aggregation assay that can be used for clinical diagnosis and treatment evaluation. |
| first_indexed | 2024-03-11T02:44:48Z |
| format | Article |
| id | doaj.art-77c88bd025584c77a54d0049c35330a8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:44:48Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-77c88bd025584c77a54d0049c35330a82023-11-18T09:26:14ZengMDPI AGBiomedicines2227-90592023-06-01116164610.3390/biomedicines11061646Pick’s Disease, Seeding an Answer to the Clinical Diagnosis ConundrumNicole Tamvaka0Sireesha Manne1Naveen Kondru2Owen A. Ross3Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USAPick’s disease (PiD) is a devastating neurodegenerative disease that is characterized by dementia, frontotemporal lobar degeneration, and the aggregation of 3R tau in pathognomonic inclusions known as Pick bodies. The term PiD has adopted many meanings since its conception in 1926, but it is currently used as a strictly neuropathological term, since PiD patients cannot be diagnosed during life. Due to its rarity, PiD remains significantly understudied, and subsequently, the etiology and pathomechanisms of the disease remain to be elucidated. The study of PiD and the preferential 3R tau accumulation that is unique to PiD is imperative in order to expand the current understanding of the disease and inform future studies and therapeutic development, since the lack of intervention strategies for tauopathies remains an unmet need. Yet, the lack of an antemortem diagnostic test for the disease has further complicated the study of PiD. The development of a clinical diagnostic assay for PiD will be a vital step in the study of the disease that will greatly contribute to therapeutic research, clinical trial design and patient recruitment and ultimately improve patient outcomes. Seed aggregation assays have shown great promise for becoming ante mortem clinical diagnostic tools for many proteinopathies, including tauopathies. Future research on adapting and optimizing current seed aggregation assays to successfully detect 3R tau pathogenic forms from PiD samples will be critical in establishing a 3R tau specific seed aggregation assay that can be used for clinical diagnosis and treatment evaluation.https://www.mdpi.com/2227-9059/11/6/1646Pick’s diseaseprimary tauopathy3R tauseed aggregation assays |
| spellingShingle | Nicole Tamvaka Sireesha Manne Naveen Kondru Owen A. Ross Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum Biomedicines Pick’s disease primary tauopathy 3R tau seed aggregation assays |
| title | Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum |
| title_full | Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum |
| title_fullStr | Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum |
| title_full_unstemmed | Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum |
| title_short | Pick’s Disease, Seeding an Answer to the Clinical Diagnosis Conundrum |
| title_sort | pick s disease seeding an answer to the clinical diagnosis conundrum |
| topic | Pick’s disease primary tauopathy 3R tau seed aggregation assays |
| url | https://www.mdpi.com/2227-9059/11/6/1646 |
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