Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates
Molecular markers detected in urine may improve our understanding of the evolution of bladder cancer (BCa) and its micro- and macroenvironment. Detection of such markers will identify disease earlier, allow stratification of patients according to risk, and improve prognostication and prediction of o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2021-09-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20210194 |
| _version_ | 1818734906020200448 |
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| author | Xuan-Mei Piao Howon Kang Wun-Jae Kim Seok Joong Yun |
| author_facet | Xuan-Mei Piao Howon Kang Wun-Jae Kim Seok Joong Yun |
| author_sort | Xuan-Mei Piao |
| collection | DOAJ |
| description | Molecular markers detected in urine may improve our understanding of the evolution of bladder cancer (BCa) and its micro- and macroenvironment. Detection of such markers will identify disease earlier, allow stratification of patients according to risk, and improve prognostication and prediction of outcomes, thereby facilitating targeted therapy. However, current guidelines have yet to embrace such markers for routine management of BCa, and most research studies have focused on urine-based tumor markers. In this review, we summarize known urinary biomarkers for BCa and highlight newly identified molecules. We then discuss the challenges that must be overcome to incorporate these markers into clinical care. |
| first_indexed | 2024-12-18T00:12:48Z |
| format | Article |
| id | doaj.art-77c9e725f23543b5b09a3d368c43e75d |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-12-18T00:12:48Z |
| publishDate | 2021-09-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-77c9e725f23543b5b09a3d368c43e75d2022-12-21T21:27:38ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2021-09-0162550051910.4111/icu.20210194Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidatesXuan-Mei Piao0https://orcid.org/0000-0001-6847-7743Howon Kang1https://orcid.org/0000-0002-8164-4427Wun-Jae Kim2https://orcid.org/0000-0002-8060-8926Seok Joong Yun 3https://orcid.org/0000-0001-7737-4746Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea.Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea.Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea.Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Korea.Molecular markers detected in urine may improve our understanding of the evolution of bladder cancer (BCa) and its micro- and macroenvironment. Detection of such markers will identify disease earlier, allow stratification of patients according to risk, and improve prognostication and prediction of outcomes, thereby facilitating targeted therapy. However, current guidelines have yet to embrace such markers for routine management of BCa, and most research studies have focused on urine-based tumor markers. In this review, we summarize known urinary biomarkers for BCa and highlight newly identified molecules. We then discuss the challenges that must be overcome to incorporate these markers into clinical care.https://www.icurology.org/pdf/10.4111/icu.20210194biomarkersdnaproteinrnaurinary bladder neoplasms |
| spellingShingle | Xuan-Mei Piao Howon Kang Wun-Jae Kim Seok Joong Yun Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates Investigative and Clinical Urology biomarkers dna protein rna urinary bladder neoplasms |
| title | Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates |
| title_full | Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates |
| title_fullStr | Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates |
| title_full_unstemmed | Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates |
| title_short | Prominence of urinary biomarkers for bladder cancer in the COVID-19 era: From the commercially available to new prospective candidates |
| title_sort | prominence of urinary biomarkers for bladder cancer in the covid 19 era from the commercially available to new prospective candidates |
| topic | biomarkers dna protein rna urinary bladder neoplasms |
| url | https://www.icurology.org/pdf/10.4111/icu.20210194 |
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