Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice

Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice

In this research, a UHPLC–MS/MS method was developed and validated for the determination of zonisamide in dried plasma spots (DPS) and dried blood spots (DBS). Detection of zonisamide and internal standard, 1-(2,3-dichlorphenyl)piperazine, was carried out in ESI+ mode by monitoring two MRM transitio...

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Bibliographic Details
Main Authors: Milena Rmandić, Ana Stajić, Jasna Jančić, Janko Samardžić, Nebojša Jović, Anđelija Malenović
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
zonisamide
dried plasma spots
dried blood spots
image processing
hematocrit
UHPLC–MS/MS method
Online Access:https://www.mdpi.com/1420-3049/27/15/4899

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