Association of COVID-19 Lockdown With Gestational Diabetes Mellitus
ImportanceThe ongoing pandemic of COVID-19 is still affecting our life, but the effects of lockdown measures on gestational diabetes mellitus (GDM) in pregnant women remain unclear.AimTo investigate the association between COVID-19 lockdown and GDM.Subjects and MethodsMedical records of 140844 pregn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.824245/full |
| _version_ | 1819159203766337536 |
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| author | Zhongrong He Zhongrong He Yanyun Lv Suijin Zheng Yudong Pu Qingmei Lin He Zhou He Zhou Moran Dong Jiaqi Wang Jingjie Fan Yufeng Ye Hanwei Chen Rui Qian Juan Jin Yumeng Chen Yumeng Chen Guimin Chen Guimin Chen Guanhao He Shouzhen Cheng Jianxiong Hu Jianpeng Xiao Wenjun Ma Wenjun Ma Xi Su Tao Liu Tao Liu |
| author_facet | Zhongrong He Zhongrong He Yanyun Lv Suijin Zheng Yudong Pu Qingmei Lin He Zhou He Zhou Moran Dong Jiaqi Wang Jingjie Fan Yufeng Ye Hanwei Chen Rui Qian Juan Jin Yumeng Chen Yumeng Chen Guimin Chen Guimin Chen Guanhao He Shouzhen Cheng Jianxiong Hu Jianpeng Xiao Wenjun Ma Wenjun Ma Xi Su Tao Liu Tao Liu |
| author_sort | Zhongrong He |
| collection | DOAJ |
| description | ImportanceThe ongoing pandemic of COVID-19 is still affecting our life, but the effects of lockdown measures on gestational diabetes mellitus (GDM) in pregnant women remain unclear.AimTo investigate the association between COVID-19 lockdown and GDM.Subjects and MethodsMedical records of 140844 pregnant women during 2015-2020 were extracted from 5 hospitals in Guangdong Province, China. Pregnant women who underwent the COVID-19 Level I lockdown (1/23 - 2/24/2020) during pregnancy were defined as the exposed group (N=20472) and pregnant women who underwent the same calendar months during 2015-2019 (1/23 - 2/24) were defined as the unexposed group (N=120372). Subgroup analyses were used to explore the potential susceptible exposure window of COVID-19 lockdown on GDM. Cumulative exposure is quantitatively estimated by assigning different weights to response periods with different exposure intensities. A logistic regression model was used to estimate the association between COVID-19 lockdown exposure and GDM.ResultsThe rates of GDM in the exposed and unexposed groups were 15.2% and 12.4%, respectively. The overall analyses showed positive associations (odds ratio, OR=1.22, 95%CI: 1.17, 1.27) between lockdown exposure and GDM risk in all pregnant women. More pronounced associations were found in women who underwent the COVID-19 lockdown in their first four months of pregnancy, and the adjusted OR values ranged from 1.24 (95%CI: 1.10, 1.39) in women with 5-8 gestational weeks (GWs) to 1.35 (95%CI: 1.20, 1.52) with < 5 GWs. In addition, we found a positive exposure-response association of cumulative lockdown exposure with the risk of GDM.ConclusionsThe COVID-19 lockdown was associated with an increased risk of GDM, and the first four months of pregnancy may be the window for sensitive exposure. |
| first_indexed | 2024-12-22T16:36:50Z |
| format | Article |
| id | doaj.art-77caf13221cd490991afc2e06bf244e9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T16:36:50Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-77caf13221cd490991afc2e06bf244e92022-12-21T18:19:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.824245824245Association of COVID-19 Lockdown With Gestational Diabetes MellitusZhongrong He0Zhongrong He1Yanyun Lv2Suijin Zheng3Yudong Pu4Qingmei Lin5He Zhou6He Zhou7Moran Dong8Jiaqi Wang9Jingjie Fan10Yufeng Ye11Hanwei Chen12Rui Qian13Juan Jin14Yumeng Chen15Yumeng Chen16Guimin Chen17Guimin Chen18Guanhao He19Shouzhen Cheng20Jianxiong Hu21Jianpeng Xiao22Wenjun Ma23Wenjun Ma24Xi Su25Tao Liu26Tao Liu27Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaAffiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, ChinaThe Affiliated Houjie Hospital, Guangdong Medical University, Dongguan, ChinaCentral Laboratory, Songshan Lake Central Hospital of Dongguan City, Dongguan, ChinaFoshan Women and Children Hospital Affiliated to Southern Medical University, Foshan, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaDepartment of Prevention and Health Care, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, ChinaRadiological Department, Guangzhou Panyu Central Hospital, Guangzhou, ChinaRadiological Department, Guangzhou Panyu Central Hospital, Guangzhou, China0Technology Department, Statistical Information Center for Health and Family Planning Bureau of Foshan, Foshan, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China1School of Public Health, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China2Nursing Department, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China3Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China4Disease Control and Prevention Institute of Jinan University, Jinan University, Guangzhou, ChinaFoshan Women and Children Hospital Affiliated to Southern Medical University, Foshan, China3Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China4Disease Control and Prevention Institute of Jinan University, Jinan University, Guangzhou, ChinaImportanceThe ongoing pandemic of COVID-19 is still affecting our life, but the effects of lockdown measures on gestational diabetes mellitus (GDM) in pregnant women remain unclear.AimTo investigate the association between COVID-19 lockdown and GDM.Subjects and MethodsMedical records of 140844 pregnant women during 2015-2020 were extracted from 5 hospitals in Guangdong Province, China. Pregnant women who underwent the COVID-19 Level I lockdown (1/23 - 2/24/2020) during pregnancy were defined as the exposed group (N=20472) and pregnant women who underwent the same calendar months during 2015-2019 (1/23 - 2/24) were defined as the unexposed group (N=120372). Subgroup analyses were used to explore the potential susceptible exposure window of COVID-19 lockdown on GDM. Cumulative exposure is quantitatively estimated by assigning different weights to response periods with different exposure intensities. A logistic regression model was used to estimate the association between COVID-19 lockdown exposure and GDM.ResultsThe rates of GDM in the exposed and unexposed groups were 15.2% and 12.4%, respectively. The overall analyses showed positive associations (odds ratio, OR=1.22, 95%CI: 1.17, 1.27) between lockdown exposure and GDM risk in all pregnant women. More pronounced associations were found in women who underwent the COVID-19 lockdown in their first four months of pregnancy, and the adjusted OR values ranged from 1.24 (95%CI: 1.10, 1.39) in women with 5-8 gestational weeks (GWs) to 1.35 (95%CI: 1.20, 1.52) with < 5 GWs. In addition, we found a positive exposure-response association of cumulative lockdown exposure with the risk of GDM.ConclusionsThe COVID-19 lockdown was associated with an increased risk of GDM, and the first four months of pregnancy may be the window for sensitive exposure.https://www.frontiersin.org/articles/10.3389/fendo.2022.824245/fullCOVID-19lockdownpregnant womangestational diabetes mellitusChina |
| spellingShingle | Zhongrong He Zhongrong He Yanyun Lv Suijin Zheng Yudong Pu Qingmei Lin He Zhou He Zhou Moran Dong Jiaqi Wang Jingjie Fan Yufeng Ye Hanwei Chen Rui Qian Juan Jin Yumeng Chen Yumeng Chen Guimin Chen Guimin Chen Guanhao He Shouzhen Cheng Jianxiong Hu Jianpeng Xiao Wenjun Ma Wenjun Ma Xi Su Tao Liu Tao Liu Association of COVID-19 Lockdown With Gestational Diabetes Mellitus Frontiers in Endocrinology COVID-19 lockdown pregnant woman gestational diabetes mellitus China |
| title | Association of COVID-19 Lockdown With Gestational Diabetes Mellitus |
| title_full | Association of COVID-19 Lockdown With Gestational Diabetes Mellitus |
| title_fullStr | Association of COVID-19 Lockdown With Gestational Diabetes Mellitus |
| title_full_unstemmed | Association of COVID-19 Lockdown With Gestational Diabetes Mellitus |
| title_short | Association of COVID-19 Lockdown With Gestational Diabetes Mellitus |
| title_sort | association of covid 19 lockdown with gestational diabetes mellitus |
| topic | COVID-19 lockdown pregnant woman gestational diabetes mellitus China |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.824245/full |
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