| Summary: | <i>Candida glabrata</i> is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated <i>Candida</i> species associated with invasive candidiasis (IC) behind <i>C. albicans</i>. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors. This work aimed to review various virulence factors that facilitate the survival of pathogenic <i>C. glabrata</i> in IC. The available published research articles related to the pathogenicity of <i>C</i>. <i>glabrata</i> were retrieved and reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, and Scopus. The articles highlighted many virulence factors associated with pathogenicity in <i>C</i>. <i>glabrata</i>, including adherence to susceptible host surfaces, evading host defences, replicative ageing, and producing hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins). The factors facilitate infection initiation. Other virulent factors include iron regulation and genetic mutations. Accordingly, biofilm production, tolerance to high-stress environments, resistance to neutrophil killings, and development of resistance to antifungal drugs, notably to fluconazole and other azole derivatives, were reported. The review provided evident pathogenic mechanisms and antifungal resistance associated with <i>C. glabrata</i> in ensuring its sustenance and survival.
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