Toxoplasma gondii infection and insomnia: A case control seroprevalence study.
We determined the association between Toxoplasma gondii (T. gondii) infection and insomnia. Through an age-and gender-matched case-control study, 577 people with insomnia (cases) and 577 people without insomnia (controls) were tested for anti-T. gondii IgG and IgM antibodies using commercially avail...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0266214 |
| _version_ | 1811295105948057600 |
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| author | Cosme Alvarado-Esquivel Sergio Estrada-Martínez Alma Rosa Pérez-Álamos Agar Ramos-Nevárez Karina Botello-Calderón Ángel Osvaldo Alvarado-Félix Raquel Vaquera-Enríquez Gustavo Alexis Alvarado-Félix Antonio Sifuentes-Álvarez Carlos Alberto Guido-Arreola Elizabeth Rábago-Sánchez Leandro Saenz-Soto |
| author_facet | Cosme Alvarado-Esquivel Sergio Estrada-Martínez Alma Rosa Pérez-Álamos Agar Ramos-Nevárez Karina Botello-Calderón Ángel Osvaldo Alvarado-Félix Raquel Vaquera-Enríquez Gustavo Alexis Alvarado-Félix Antonio Sifuentes-Álvarez Carlos Alberto Guido-Arreola Elizabeth Rábago-Sánchez Leandro Saenz-Soto |
| author_sort | Cosme Alvarado-Esquivel |
| collection | DOAJ |
| description | We determined the association between Toxoplasma gondii (T. gondii) infection and insomnia. Through an age-and gender-matched case-control study, 577 people with insomnia (cases) and 577 people without insomnia (controls) were tested for anti-T. gondii IgG and IgM antibodies using commercially available enzyme-immunoassays. Anti-T. gondii IgG antibodies were found in 71 (12.3%) of 577 individuals with insomnia and in 46 (8.0%) of 577 controls (OR = 1.62; 95% CI: 1.09-2.39; P = 0.01). Men with insomnia had a higher (16/73: 21.9%) seroprevalence of T. gondii infection than men without insomnia (5/73: 6.8%) (OR: 3.81; 95% CI: 1.31-11.06; P = 0.009). The rate of high (>150 IU/ml) anti-T. gondii IgG antibody levels in cases was higher than the one in controls (OR = 2.21; 95% CI: 1.13-4.31; P = 0.01). Men with insomnia had a higher (8/73: 11.0%) rate of high anti-T. gondii IgG antibody levels than men without insomnia (0/73: 0.0%) (P = 0.006). The rate of high anti-T. gondii IgG antibody levels in cases >50 years old (11/180: 6.1%) was higher than that (3/180: 1.7%) in controls of the same age group (OR: 3.84; 95% CI: 1.05-14.00; P = 0.05). No difference in the rate of IgM seropositivity between cases and controls was found (OR = 1.33; 95% CI: 0.57-3.11; P = 0.50). Results of this seroepidemiology study suggest that infection with T. gondii is associated with insomnia. Men older than 50 years with T. gondii exposure might be prone to insomnia. Further research to confirm the association between seropositivity and serointensity to T. gondii and insomnia is needed. |
| first_indexed | 2024-04-13T05:27:36Z |
| format | Article |
| id | doaj.art-77cc933d5cc34c46971c90c243c3bffd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T05:27:36Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-77cc933d5cc34c46971c90c243c3bffd2022-12-22T03:00:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176e026621410.1371/journal.pone.0266214Toxoplasma gondii infection and insomnia: A case control seroprevalence study.Cosme Alvarado-EsquivelSergio Estrada-MartínezAlma Rosa Pérez-ÁlamosAgar Ramos-NevárezKarina Botello-CalderónÁngel Osvaldo Alvarado-FélixRaquel Vaquera-EnríquezGustavo Alexis Alvarado-FélixAntonio Sifuentes-ÁlvarezCarlos Alberto Guido-ArreolaElizabeth Rábago-SánchezLeandro Saenz-SotoWe determined the association between Toxoplasma gondii (T. gondii) infection and insomnia. Through an age-and gender-matched case-control study, 577 people with insomnia (cases) and 577 people without insomnia (controls) were tested for anti-T. gondii IgG and IgM antibodies using commercially available enzyme-immunoassays. Anti-T. gondii IgG antibodies were found in 71 (12.3%) of 577 individuals with insomnia and in 46 (8.0%) of 577 controls (OR = 1.62; 95% CI: 1.09-2.39; P = 0.01). Men with insomnia had a higher (16/73: 21.9%) seroprevalence of T. gondii infection than men without insomnia (5/73: 6.8%) (OR: 3.81; 95% CI: 1.31-11.06; P = 0.009). The rate of high (>150 IU/ml) anti-T. gondii IgG antibody levels in cases was higher than the one in controls (OR = 2.21; 95% CI: 1.13-4.31; P = 0.01). Men with insomnia had a higher (8/73: 11.0%) rate of high anti-T. gondii IgG antibody levels than men without insomnia (0/73: 0.0%) (P = 0.006). The rate of high anti-T. gondii IgG antibody levels in cases >50 years old (11/180: 6.1%) was higher than that (3/180: 1.7%) in controls of the same age group (OR: 3.84; 95% CI: 1.05-14.00; P = 0.05). No difference in the rate of IgM seropositivity between cases and controls was found (OR = 1.33; 95% CI: 0.57-3.11; P = 0.50). Results of this seroepidemiology study suggest that infection with T. gondii is associated with insomnia. Men older than 50 years with T. gondii exposure might be prone to insomnia. Further research to confirm the association between seropositivity and serointensity to T. gondii and insomnia is needed.https://doi.org/10.1371/journal.pone.0266214 |
| spellingShingle | Cosme Alvarado-Esquivel Sergio Estrada-Martínez Alma Rosa Pérez-Álamos Agar Ramos-Nevárez Karina Botello-Calderón Ángel Osvaldo Alvarado-Félix Raquel Vaquera-Enríquez Gustavo Alexis Alvarado-Félix Antonio Sifuentes-Álvarez Carlos Alberto Guido-Arreola Elizabeth Rábago-Sánchez Leandro Saenz-Soto Toxoplasma gondii infection and insomnia: A case control seroprevalence study. PLoS ONE |
| title | Toxoplasma gondii infection and insomnia: A case control seroprevalence study. |
| title_full | Toxoplasma gondii infection and insomnia: A case control seroprevalence study. |
| title_fullStr | Toxoplasma gondii infection and insomnia: A case control seroprevalence study. |
| title_full_unstemmed | Toxoplasma gondii infection and insomnia: A case control seroprevalence study. |
| title_short | Toxoplasma gondii infection and insomnia: A case control seroprevalence study. |
| title_sort | toxoplasma gondii infection and insomnia a case control seroprevalence study |
| url | https://doi.org/10.1371/journal.pone.0266214 |
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