SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4<sup>+</sup> T-lymphocytes cannot be upregulated by interferons

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4<sup>+</sup> T-lymphocytes cannot be upregulated by interferons

<p>Abstract</p> <p>Background</p> <p>SAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4<sup>+</sup> T-cells. Acting as a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, SAMHD1 hydroly...

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Bibliographic Details
Main Authors: St Gelais Corine, de Silva Suresh, Amie Sarah M, Coleman Christopher M, Hoy Heather, Hollenbaugh Joseph A, Kim Baek, Wu Li
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Retrovirology
Subjects:
HIV-1 restriction
SAMHD1
Dendritic cells
Interferon
Intracellular dNTPs
Online Access:http://www.retrovirology.com/content/9/1/105

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