Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes
Band 3 protein (B3p) exchanging Cl<sup>−</sup> and HCO<sub>3</sub><sup>−</sup> through erythrocyte membranes is responsible for acid balance, ion distribution and gas exchange, thus accounting for homeostasis of both erythrocytes and entire org...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/1/25 |
| _version_ | 1797761921581056000 |
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| author | Alessia Remigante Rossana Morabito Angela Marino |
| author_facet | Alessia Remigante Rossana Morabito Angela Marino |
| author_sort | Alessia Remigante |
| collection | DOAJ |
| description | Band 3 protein (B3p) exchanging Cl<sup>−</sup> and HCO<sub>3</sub><sup>−</sup> through erythrocyte membranes is responsible for acid balance, ion distribution and gas exchange, thus accounting for homeostasis of both erythrocytes and entire organisms. Moreover, since B3p cross links with the cytoskeleton and the proteins underlying the erythrocyte membrane, its function also impacts cell shape and deformability, essential to adaptation of erythrocyte size to capillaries for pulmonary circulation. As growing attention has been directed toward this protein in recent years, the present review was conceived to report the most recent knowledge regarding B3p, with specific regard to its anion exchange capability under in vitro oxidative conditions. Most importantly, the role of natural antioxidants, i.e., curcumin, melatonin and Mg<sup>2+</sup>, in preventing detrimental oxidant effects on B3p is considered. |
| first_indexed | 2024-03-12T19:19:57Z |
| format | Article |
| id | doaj.art-77ccf5ebc88e426dab87773e0a955a4f |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:19:57Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-77ccf5ebc88e426dab87773e0a955a4f2023-08-02T05:13:43ZengMDPI AGAntioxidants2076-39212019-12-01912510.3390/antiox9010025antiox9010025Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human ErythrocytesAlessia Remigante0Rossana Morabito1Angela Marino2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D’Alcontres 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D’Alcontres 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D’Alcontres 31, 98166 Messina, ItalyBand 3 protein (B3p) exchanging Cl<sup>−</sup> and HCO<sub>3</sub><sup>−</sup> through erythrocyte membranes is responsible for acid balance, ion distribution and gas exchange, thus accounting for homeostasis of both erythrocytes and entire organisms. Moreover, since B3p cross links with the cytoskeleton and the proteins underlying the erythrocyte membrane, its function also impacts cell shape and deformability, essential to adaptation of erythrocyte size to capillaries for pulmonary circulation. As growing attention has been directed toward this protein in recent years, the present review was conceived to report the most recent knowledge regarding B3p, with specific regard to its anion exchange capability under in vitro oxidative conditions. Most importantly, the role of natural antioxidants, i.e., curcumin, melatonin and Mg<sup>2+</sup>, in preventing detrimental oxidant effects on B3p is considered.https://www.mdpi.com/2076-3921/9/1/25erythrocytesband 3 proteinanion exchangeso<sub>4</sub><sup>=</sup>oxidative stressantioxidants |
| spellingShingle | Alessia Remigante Rossana Morabito Angela Marino Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes Antioxidants erythrocytes band 3 protein anion exchange so<sub>4</sub><sup>=</sup> oxidative stress antioxidants |
| title | Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes |
| title_full | Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes |
| title_fullStr | Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes |
| title_full_unstemmed | Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes |
| title_short | Natural Antioxidants Beneficial Effects on Anion Exchange through Band 3 Protein in Human Erythrocytes |
| title_sort | natural antioxidants beneficial effects on anion exchange through band 3 protein in human erythrocytes |
| topic | erythrocytes band 3 protein anion exchange so<sub>4</sub><sup>=</sup> oxidative stress antioxidants |
| url | https://www.mdpi.com/2076-3921/9/1/25 |
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