Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience
Background Immunophenotyping and enumeration of plasma cells (PCs) by flow cytometry are deemed to be prognostically significant. However, PCs enumeration by flow cytometry is challenging owing to discrepancy with morphology and PCs loss during sample processing. Enumeration and different...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2023-09-01
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| Series: | Journal of Laboratory Physicians |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761204 |
| _version_ | 1797755157317943296 |
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| author | Asish Rath Tribikram Panda Jasmita Dass Tulika Seth Manoranjan Mahapatra Seema Tyagi |
| author_facet | Asish Rath Tribikram Panda Jasmita Dass Tulika Seth Manoranjan Mahapatra Seema Tyagi |
| author_sort | Asish Rath |
| collection | DOAJ |
| description |
Background Immunophenotyping and enumeration of plasma cells (PCs) by flow cytometry are deemed to be prognostically significant. However, PCs enumeration by flow cytometry is challenging owing to discrepancy with morphology and PCs loss during sample processing. Enumeration and differentiation of abnormal plasma cells (APCs) and normal plasma cells (NPCs) is difficult because abnormal antigen expression can be seen in subsets of NPCs. This is particularly true when a limited panel of antibodies are relied upon. |
| first_indexed | 2024-03-12T17:42:44Z |
| format | Article |
| id | doaj.art-77cd042864444200a2277d005396a3b7 |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-03-12T17:42:44Z |
| publishDate | 2023-09-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-77cd042864444200a2277d005396a3b72023-08-03T23:21:11ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262023-09-01150339239810.1055/s-0043-1761204Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre ExperienceAsish Rath0https://orcid.org/0000-0002-4528-0590Tribikram Panda1Jasmita Dass2Tulika Seth3Manoranjan Mahapatra4Seema Tyagi5Department of Hematology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, India Background Immunophenotyping and enumeration of plasma cells (PCs) by flow cytometry are deemed to be prognostically significant. However, PCs enumeration by flow cytometry is challenging owing to discrepancy with morphology and PCs loss during sample processing. Enumeration and differentiation of abnormal plasma cells (APCs) and normal plasma cells (NPCs) is difficult because abnormal antigen expression can be seen in subsets of NPCs. This is particularly true when a limited panel of antibodies are relied upon.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761204multiple myelomaimmunophenotypeflow cytometryCD38MFI |
| spellingShingle | Asish Rath Tribikram Panda Jasmita Dass Tulika Seth Manoranjan Mahapatra Seema Tyagi Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience Journal of Laboratory Physicians multiple myeloma immunophenotype flow cytometry CD38MFI |
| title | Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience |
| title_full | Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience |
| title_fullStr | Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience |
| title_full_unstemmed | Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience |
| title_short | Immunophenotypic Profile of Multiple Myeloma: A Tertiary Care Centre Experience |
| title_sort | immunophenotypic profile of multiple myeloma a tertiary care centre experience |
| topic | multiple myeloma immunophenotype flow cytometry CD38MFI |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761204 |
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