Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good
Abstract The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40246-019-0229-z |
| _version_ | 1818007316569522176 |
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| author | Kristi Krebs Lili Milani |
| author_facet | Kristi Krebs Lili Milani |
| author_sort | Kristi Krebs |
| collection | DOAJ |
| description | Abstract The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress in the field of pharmacogenomics, its implementation into routine care has been slow due to several barriers. However, in recent years, the number of studies on the implementation of PGx has increased, all providing a wealth of knowledge on different solutions for overcoming the obstacles that have been emphasized over the past years. This review focuses on some of the challenges faced by these initiatives, the solutions and different approaches for testing that they suggest, and the evidence that they provide regarding the benefits of preemptive PGx testing. |
| first_indexed | 2024-04-14T05:13:41Z |
| format | Article |
| id | doaj.art-77ce88fb813445cb86ba945ab953b6f4 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-14T05:13:41Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-77ce88fb813445cb86ba945ab953b6f42022-12-22T02:10:26ZengBMCHuman Genomics1479-73642019-08-0113111310.1186/s40246-019-0229-zTranslating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the goodKristi Krebs0Lili Milani1Estonian Genome Center, Institute of Genomics, University of TartuEstonian Genome Center, Institute of Genomics, University of TartuAbstract The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce adverse events, and decrease the burden of unnecessary costs for healthcare systems. Despite the progress in the field of pharmacogenomics, its implementation into routine care has been slow due to several barriers. However, in recent years, the number of studies on the implementation of PGx has increased, all providing a wealth of knowledge on different solutions for overcoming the obstacles that have been emphasized over the past years. This review focuses on some of the challenges faced by these initiatives, the solutions and different approaches for testing that they suggest, and the evidence that they provide regarding the benefits of preemptive PGx testing.http://link.springer.com/article/10.1186/s40246-019-0229-zPharmacogeneticsPharmacogenomicsPGxImplementation of pharmacogeneticsTranslation into the clinicClinical decision support |
| spellingShingle | Kristi Krebs Lili Milani Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good Human Genomics Pharmacogenetics Pharmacogenomics PGx Implementation of pharmacogenetics Translation into the clinic Clinical decision support |
| title | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
| title_full | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
| title_fullStr | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
| title_full_unstemmed | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
| title_short | Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good |
| title_sort | translating pharmacogenomics into clinical decisions do not let the perfect be the enemy of the good |
| topic | Pharmacogenetics Pharmacogenomics PGx Implementation of pharmacogenetics Translation into the clinic Clinical decision support |
| url | http://link.springer.com/article/10.1186/s40246-019-0229-z |
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