The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities
Benign prostatic hyperplasia (BPH) is one of the most common causes of lower urinary tract symptoms (LUTS) in men, which is characterized by a noncancerous enlargement of the prostate. BPH troubles the vast majority of aging men worldwide; however, the pathogenetic factors of BPH have not been compl...
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MDPI AG
2022-06-01
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| Series: | Cells |
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| author | Xun Fu Huan Liu Jiang Liu Michael E. DiSanto Xinhua Zhang |
| author_facet | Xun Fu Huan Liu Jiang Liu Michael E. DiSanto Xinhua Zhang |
| author_sort | Xun Fu |
| collection | DOAJ |
| description | Benign prostatic hyperplasia (BPH) is one of the most common causes of lower urinary tract symptoms (LUTS) in men, which is characterized by a noncancerous enlargement of the prostate. BPH troubles the vast majority of aging men worldwide; however, the pathogenetic factors of BPH have not been completely identified. The heat shock protein 70 (HSP70) subfamily, which mainly includes HSP70, glucose-regulated protein 78 (GRP78) and GRP75, plays a crucial role in maintaining cellular homeostasis. HSP70s are overexpressed in the course of BPH and involved in a variety of biological processes, such as cell survival and proliferation, cell apoptosis, epithelial/mesenchymal transition (EMT) and fibrosis, contributing to the development and progress of prostate diseases. These chaperone proteins also participate in oxidative stress, a cellular stress response that takes place under stress conditions. In addition, HSP70s can bind to the androgen receptor (AR) and act as a regulator of AR activity. This interaction of HSP70s with AR provides insight into the importance of the HSP70 chaperone family in BPH pathogenesis. In this review, we discuss the function of the HSP70 family in prostate glands and the role of HSP70s in the course of BPH. We also review the potential applications of HSP70s as biomarkers of prostate diseases for targeted therapies. |
| first_indexed | 2024-03-09T22:01:37Z |
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| id | doaj.art-77d46a82ddf5430a9454c7875ad38802 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:01:37Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-77d46a82ddf5430a9454c7875ad388022023-11-23T19:48:40ZengMDPI AGCells2073-44092022-06-011113205210.3390/cells11132052The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic OpportunitiesXun Fu0Huan Liu1Jiang Liu2Michael E. DiSanto3Xinhua Zhang4Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430000, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430000, ChinaDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430000, ChinaDepartment of Surgery and Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08028, USADepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430000, ChinaBenign prostatic hyperplasia (BPH) is one of the most common causes of lower urinary tract symptoms (LUTS) in men, which is characterized by a noncancerous enlargement of the prostate. BPH troubles the vast majority of aging men worldwide; however, the pathogenetic factors of BPH have not been completely identified. The heat shock protein 70 (HSP70) subfamily, which mainly includes HSP70, glucose-regulated protein 78 (GRP78) and GRP75, plays a crucial role in maintaining cellular homeostasis. HSP70s are overexpressed in the course of BPH and involved in a variety of biological processes, such as cell survival and proliferation, cell apoptosis, epithelial/mesenchymal transition (EMT) and fibrosis, contributing to the development and progress of prostate diseases. These chaperone proteins also participate in oxidative stress, a cellular stress response that takes place under stress conditions. In addition, HSP70s can bind to the androgen receptor (AR) and act as a regulator of AR activity. This interaction of HSP70s with AR provides insight into the importance of the HSP70 chaperone family in BPH pathogenesis. In this review, we discuss the function of the HSP70 family in prostate glands and the role of HSP70s in the course of BPH. We also review the potential applications of HSP70s as biomarkers of prostate diseases for targeted therapies.https://www.mdpi.com/2073-4409/11/13/2052BPHLUTSHSP70 subfamilyHSP70stargeted therapies |
| spellingShingle | Xun Fu Huan Liu Jiang Liu Michael E. DiSanto Xinhua Zhang The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities Cells BPH LUTS HSP70 subfamily HSP70s targeted therapies |
| title | The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities |
| title_full | The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities |
| title_fullStr | The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities |
| title_full_unstemmed | The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities |
| title_short | The Role of Heat Shock Protein 70 Subfamily in the Hyperplastic Prostate: From Molecular Mechanisms to Therapeutic Opportunities |
| title_sort | role of heat shock protein 70 subfamily in the hyperplastic prostate from molecular mechanisms to therapeutic opportunities |
| topic | BPH LUTS HSP70 subfamily HSP70s targeted therapies |
| url | https://www.mdpi.com/2073-4409/11/13/2052 |
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