Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk

Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA methylation and transcription phenotypes share genetic variation with schizophrenia risk

Abstract DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an important role in the regulation of gene expression. Single-nucleotide polymorphisms (SNPs) associated with schizophrenia (SZ) by genome-wide association studies (GWAS) often influence local DNAm levels. T...

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Bibliographic Details
Main Authors: Brandon C. McKinney, Lora L. McClain, Christopher M. Hensler, Yue Wei, Lambertus Klei, David A. Lewis, Bernie Devlin, Jiebiao Wang, Ying Ding, Robert A. Sweet
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02071-0

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