Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient
Human embryonic stem cell (hESC) line was derived from abnormal blastocyst donated by Marfan syndrome patient after preimpantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that the hESC line carried the heterozygous deletion mutation, c.3536delA, of FBN1 gene. Characteris...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-11-01
|
| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506115001476 |
| _version_ | 1818194131239829504 |
|---|---|
| author | Qingqing Yang Xiaoying Zhou Hao Zhou Long Li Juan Du Guangxiu Lu Ge Lin Qi Ouyang |
| author_facet | Qingqing Yang Xiaoying Zhou Hao Zhou Long Li Juan Du Guangxiu Lu Ge Lin Qi Ouyang |
| author_sort | Qingqing Yang |
| collection | DOAJ |
| description | Human embryonic stem cell (hESC) line was derived from abnormal blastocyst donated by Marfan syndrome patient after preimpantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that the hESC line carried the heterozygous deletion mutation, c.3536delA, of FBN1 gene. Characteristic tests proved that the hESC line presented typical markers of pluripotency and had the capability to form the three germ layers both in vitro and in vivo. |
| first_indexed | 2024-12-12T00:57:25Z |
| format | Article |
| id | doaj.art-77d8baebff344158990bcaa520727d33 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 1876-7753 |
| language | English |
| last_indexed | 2024-12-12T00:57:25Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-77d8baebff344158990bcaa520727d332022-12-22T00:43:50ZengElsevierStem Cell Research1873-50611876-77532015-11-0115364064210.1016/j.scr.2015.10.012Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patientQingqing Yang0Xiaoying Zhou1Hao Zhou2Long Li3Juan Du4Guangxiu Lu5Ge Lin6Qi Ouyang7Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaNational Engineering and Research Center of Human Stem Cell, Changsha, ChinaInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaNational Engineering and Research Center of Human Stem Cell, Changsha, ChinaInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaInstitute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaHuman embryonic stem cell (hESC) line was derived from abnormal blastocyst donated by Marfan syndrome patient after preimpantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that the hESC line carried the heterozygous deletion mutation, c.3536delA, of FBN1 gene. Characteristic tests proved that the hESC line presented typical markers of pluripotency and had the capability to form the three germ layers both in vitro and in vivo.http://www.sciencedirect.com/science/article/pii/S1873506115001476 |
| spellingShingle | Qingqing Yang Xiaoying Zhou Hao Zhou Long Li Juan Du Guangxiu Lu Ge Lin Qi Ouyang Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient Stem Cell Research |
| title | Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient |
| title_full | Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient |
| title_fullStr | Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient |
| title_full_unstemmed | Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient |
| title_short | Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient |
| title_sort | human embryonic stem cells derived from abnormal blastocyst donated by marfan syndrome patient |
| url | http://www.sciencedirect.com/science/article/pii/S1873506115001476 |
| work_keys_str_mv | AT qingqingyang humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT xiaoyingzhou humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT haozhou humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT longli humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT juandu humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT guangxiulu humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT gelin humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient AT qiouyang humanembryonicstemcellsderivedfromabnormalblastocystdonatedbymarfansyndromepatient |