Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes
Acute-on-chronic liver failure (ACLF) is an acute syndrome accompanied with decompensation of cirrhosis, organ failure with high 28-day mortality rate. Systemic inflammation is the main feature of ACLF, and poor outcome is closely related with exacerbated systemic inflammatory responses. It is well...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2020.583423/full |
| _version_ | 1831810744551735296 |
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| author | Qian Li Jun Wang Mengji Lu Yuanwang Qiu Hongzhou Lu |
| author_facet | Qian Li Jun Wang Mengji Lu Yuanwang Qiu Hongzhou Lu |
| author_sort | Qian Li |
| collection | DOAJ |
| description | Acute-on-chronic liver failure (ACLF) is an acute syndrome accompanied with decompensation of cirrhosis, organ failure with high 28-day mortality rate. Systemic inflammation is the main feature of ACLF, and poor outcome is closely related with exacerbated systemic inflammatory responses. It is well known that severe systemic inflammation is an important event in chronic hepatitis B (CHB)-ACLF, which eventually leads to liver injury. However, the initial CHB-ACLF events are unclear; moreover, the effect of these events on host immunity as well as that of immune imbalance on CHB-ACLF progression are unknown. Here, we investigate the initial events of ACLF progression, discuss possible mechanisms underlying ACLF progression, and provide a new model for ACLF prediction and treatment. We review the characteristics of ACLF, and consider its plausible immune predictors and alternative treatment strategies. |
| first_indexed | 2024-12-22T21:05:11Z |
| format | Article |
| id | doaj.art-77d9d68d825849c9a48e7079e4ed8031 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T21:05:11Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-77d9d68d825849c9a48e7079e4ed80312022-12-21T18:12:42ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-12-011110.3389/fmicb.2020.583423583423Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind ScenesQian Li0Jun Wang1Mengji Lu2Yuanwang Qiu3Hongzhou Lu4Department of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, ChinaCenter of Clinical Laboratory, The Fifth People’s Hospital of Wuxi, Jiangnan University, Wuxi, ChinaInstitute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, GermanyDepartment of Hepatology, The Fifth People’s Hospital of Wuxi, Jiangnan University, Wuxi, ChinaDepartment of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, ChinaAcute-on-chronic liver failure (ACLF) is an acute syndrome accompanied with decompensation of cirrhosis, organ failure with high 28-day mortality rate. Systemic inflammation is the main feature of ACLF, and poor outcome is closely related with exacerbated systemic inflammatory responses. It is well known that severe systemic inflammation is an important event in chronic hepatitis B (CHB)-ACLF, which eventually leads to liver injury. However, the initial CHB-ACLF events are unclear; moreover, the effect of these events on host immunity as well as that of immune imbalance on CHB-ACLF progression are unknown. Here, we investigate the initial events of ACLF progression, discuss possible mechanisms underlying ACLF progression, and provide a new model for ACLF prediction and treatment. We review the characteristics of ACLF, and consider its plausible immune predictors and alternative treatment strategies.https://www.frontiersin.org/articles/10.3389/fmicb.2020.583423/fullACLFHBV—hepatitis B virusB cellsinflammationcytokines storm |
| spellingShingle | Qian Li Jun Wang Mengji Lu Yuanwang Qiu Hongzhou Lu Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes Frontiers in Microbiology ACLF HBV—hepatitis B virus B cells inflammation cytokines storm |
| title | Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes |
| title_full | Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes |
| title_fullStr | Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes |
| title_full_unstemmed | Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes |
| title_short | Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes |
| title_sort | acute on chronic liver failure from chronic hepatitis b who is the behind scenes |
| topic | ACLF HBV—hepatitis B virus B cells inflammation cytokines storm |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2020.583423/full |
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