Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal?
Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a male predominance. The aim of the study was to explore gender differences in a well-designed French multicentre prospective IPF cohort (COhorte FIbrose, COFI) with a 5-year follow-up.Methods: Between 2007 and 2010, 236 patients wi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.713698/full |
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| author | Lucile Sesé Lucile Sesé Lucile Sesé Lucile Sesé Hilario Nunes Hilario Nunes Vincent Cottin Dominique Israel-Biet Bruno Crestani Stephanie Guillot-Dudoret Jacques Cadranel Benoit Wallaert Abdellatif Tazi Bernard Maître Gregoire Prévot Sylvain Marchand-Adam Sandrine Hirschi Sandra Dury Violaine Giraud Violaine Giraud Anne Gondouin Philippe Bonniaud Julie Traclet Karine Juvin Raphael Borie Zohra Carton Olivia Freynet Thomas Gille Thomas Gille Carole Planès Carole Planès Dominique Valeyre Dominique Valeyre Yurdagül Uzunhan Yurdagül Uzunhan |
| author_facet | Lucile Sesé Lucile Sesé Lucile Sesé Lucile Sesé Hilario Nunes Hilario Nunes Vincent Cottin Dominique Israel-Biet Bruno Crestani Stephanie Guillot-Dudoret Jacques Cadranel Benoit Wallaert Abdellatif Tazi Bernard Maître Gregoire Prévot Sylvain Marchand-Adam Sandrine Hirschi Sandra Dury Violaine Giraud Violaine Giraud Anne Gondouin Philippe Bonniaud Julie Traclet Karine Juvin Raphael Borie Zohra Carton Olivia Freynet Thomas Gille Thomas Gille Carole Planès Carole Planès Dominique Valeyre Dominique Valeyre Yurdagül Uzunhan Yurdagül Uzunhan |
| author_sort | Lucile Sesé |
| collection | DOAJ |
| description | Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a male predominance. The aim of the study was to explore gender differences in a well-designed French multicentre prospective IPF cohort (COhorte FIbrose, COFI) with a 5-year follow-up.Methods: Between 2007 and 2010, 236 patients with incident IPF were included in COFI. Gender characteristics were compared using a t-test, Chi-squared test and ANOVA, as appropriate. Survival analyses were performed.Results: Fifty-one (22%) females and 185 (78%) males with an average age at diagnosis of 70.1 ± 9.20 and 67.4 ± 10.9 years, respectively, were included in the cohort. Women were significantly less exposed to tobacco smoke [never n = 32 (62.7%) vs. n = 39 (21.1%), p < 0.001] and to occupational exposure [n = 7 (13.7%) vs. n = 63 (34.1%), p = 0.012]. Baseline forced vital capacity, % of predicted (FVC%) was significantly better in women compare to men (83.0% ± 25.0 v. 75.4% ± 18.7 p = 0.046). At presentation honeycombing and emphysema on CT scan were less common in women [n = 40 (78.4%) vs. n = 167 (90.3%) p = 0.041] and [n = 6 (11.8%) vs. n = 48 (25.9%) p = 0.029], respectively. During follow-up fewer women were transplanted compared to men [n = 1 (1.96%) vs. n = 20 (10.8%) p = 0.039]. Medians of survival were comparable by gender [31 months (CI 95%: 28–40) vs. 40 months (CI 95%: 33–72) p = 0.2]. After adjusting for age and FVC at inclusion, being a woman was not associated to a better survival.Conclusions: Women appear to have less advanced disease at diagnosis, maybe due to less exposure history compare to men. Disease progression and overall survival remains comparable regardless gender, but women have less access to lung transplantation. |
| first_indexed | 2024-12-16T12:51:15Z |
| format | Article |
| id | doaj.art-77da8e079275450d857dd370176cc2a1 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-16T12:51:15Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-77da8e079275450d857dd370176cc2a12022-12-21T22:31:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-08-01810.3389/fmed.2021.713698713698Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal?Lucile Sesé0Lucile Sesé1Lucile Sesé2Lucile Sesé3Hilario Nunes4Hilario Nunes5Vincent Cottin6Dominique Israel-Biet7Bruno Crestani8Stephanie Guillot-Dudoret9Jacques Cadranel10Benoit Wallaert11Abdellatif Tazi12Bernard Maître13Gregoire Prévot14Sylvain Marchand-Adam15Sandrine Hirschi16Sandra Dury17Violaine Giraud18Violaine Giraud19Anne Gondouin20Philippe Bonniaud21Julie Traclet22Karine Juvin23Raphael Borie24Zohra Carton25Olivia Freynet26Thomas Gille27Thomas Gille28Carole Planès29Carole Planès30Dominique Valeyre31Dominique Valeyre32Yurdagül Uzunhan33Yurdagül Uzunhan34AP-HP, Service de Physiologie, Hôpital Avicenne, Bobigny, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, FranceEPAR, IPLESP UMR-S 1136, INSERM et Sorbonne Université, Paris, FranceINSERM UMR 1272 “Hypoxia and the Lung,” Université Sorbonne Paris Nord, Bobigny, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, FranceINSERM UMR 1272 “Hypoxia and the Lung,” Université Sorbonne Paris Nord, Bobigny, FranceCentre Coordonnateur de Référence des Maladies Pulmonaires Rares, Hôpital Louis Pradel, Hospices Civils de Lyon, Université Lyon 1, Université de Lyon, INRAE, OrphaLung, Member of Respifil, ERN-LUNG, Lyon, FranceCentre de Compétence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital HEGP, Paris, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares AP-HP, Service de Pneumologie, Hôpital Bichat, Paris, FranceCentre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Pontchaillou, Rennes, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Tenon and Sorbonne University, Paris, France0Centre Constitutif de Référence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Albert Calmette, Lille, France1Université de Paris, Centre de Référence National des Histiocytoses, AP-HP, Service de Pneumologie, Hôpital Saint-Louis, Paris, France2AP-HP, Service de Pneumologie, Hôpital Henri-Mondor, Créteil, France3Service de Pneumologie, Hôpital Larrey, Toulouse, France4Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Bretonneau, Tours, France5Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Nouvel Hôpital Civil, Strasbourg, France6Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Maison Blanche, Reims, France5Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Nouvel Hôpital Civil, Strasbourg, France7AP-HP, Service de Pneumologie, Hôpital Ambroise Paré, Boulogne, France8Centre de Compétence des Maladies Pulmonaires Rares, Service de Pneumologie, Hôpital Jean Minjoz, Besançon, France9Centre Constitutif de référence des Maladies Pulmonaires Rares, Service de Pneumologie, Centre Hospitalier Universitaire Dijon Bourgogne, Dijon, FranceCentre Coordonnateur de Référence des Maladies Pulmonaires Rares, Hôpital Louis Pradel, Hospices Civils de Lyon, Université Lyon 1, Université de Lyon, INRAE, OrphaLung, Member of Respifil, ERN-LUNG, Lyon, FranceCentre de Compétence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital HEGP, Paris, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares AP-HP, Service de Pneumologie, Hôpital Bichat, Paris, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, FranceAP-HP, Service de Physiologie, Hôpital Avicenne, Bobigny, FranceINSERM UMR 1272 “Hypoxia and the Lung,” Université Sorbonne Paris Nord, Bobigny, FranceAP-HP, Service de Physiologie, Hôpital Avicenne, Bobigny, FranceINSERM UMR 1272 “Hypoxia and the Lung,” Université Sorbonne Paris Nord, Bobigny, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, FranceINSERM UMR 1272 “Hypoxia and the Lung,” Université Sorbonne Paris Nord, Bobigny, FranceCentre Constitutif de Référence des Maladies Pulmonaires Rares, AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, FranceINSERM UMR 1272 “Hypoxia and the Lung,” Université Sorbonne Paris Nord, Bobigny, FranceBackground: Idiopathic pulmonary fibrosis (IPF) is characterized by a male predominance. The aim of the study was to explore gender differences in a well-designed French multicentre prospective IPF cohort (COhorte FIbrose, COFI) with a 5-year follow-up.Methods: Between 2007 and 2010, 236 patients with incident IPF were included in COFI. Gender characteristics were compared using a t-test, Chi-squared test and ANOVA, as appropriate. Survival analyses were performed.Results: Fifty-one (22%) females and 185 (78%) males with an average age at diagnosis of 70.1 ± 9.20 and 67.4 ± 10.9 years, respectively, were included in the cohort. Women were significantly less exposed to tobacco smoke [never n = 32 (62.7%) vs. n = 39 (21.1%), p < 0.001] and to occupational exposure [n = 7 (13.7%) vs. n = 63 (34.1%), p = 0.012]. Baseline forced vital capacity, % of predicted (FVC%) was significantly better in women compare to men (83.0% ± 25.0 v. 75.4% ± 18.7 p = 0.046). At presentation honeycombing and emphysema on CT scan were less common in women [n = 40 (78.4%) vs. n = 167 (90.3%) p = 0.041] and [n = 6 (11.8%) vs. n = 48 (25.9%) p = 0.029], respectively. During follow-up fewer women were transplanted compared to men [n = 1 (1.96%) vs. n = 20 (10.8%) p = 0.039]. Medians of survival were comparable by gender [31 months (CI 95%: 28–40) vs. 40 months (CI 95%: 33–72) p = 0.2]. After adjusting for age and FVC at inclusion, being a woman was not associated to a better survival.Conclusions: Women appear to have less advanced disease at diagnosis, maybe due to less exposure history compare to men. Disease progression and overall survival remains comparable regardless gender, but women have less access to lung transplantation.https://www.frontiersin.org/articles/10.3389/fmed.2021.713698/fullidiopathic pulmonary fibrosisgender differencesoccupational exposureslung transplantationwomen |
| spellingShingle | Lucile Sesé Lucile Sesé Lucile Sesé Lucile Sesé Hilario Nunes Hilario Nunes Vincent Cottin Dominique Israel-Biet Bruno Crestani Stephanie Guillot-Dudoret Jacques Cadranel Benoit Wallaert Abdellatif Tazi Bernard Maître Gregoire Prévot Sylvain Marchand-Adam Sandrine Hirschi Sandra Dury Violaine Giraud Violaine Giraud Anne Gondouin Philippe Bonniaud Julie Traclet Karine Juvin Raphael Borie Zohra Carton Olivia Freynet Thomas Gille Thomas Gille Carole Planès Carole Planès Dominique Valeyre Dominique Valeyre Yurdagül Uzunhan Yurdagül Uzunhan Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal? Frontiers in Medicine idiopathic pulmonary fibrosis gender differences occupational exposures lung transplantation women |
| title | Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal? |
| title_full | Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal? |
| title_fullStr | Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal? |
| title_full_unstemmed | Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal? |
| title_short | Gender Differences in Idiopathic Pulmonary Fibrosis: Are Men and Women Equal? |
| title_sort | gender differences in idiopathic pulmonary fibrosis are men and women equal |
| topic | idiopathic pulmonary fibrosis gender differences occupational exposures lung transplantation women |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.713698/full |
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