Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.
<h4>Background</h4>Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart dis...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23408959/pdf/?tool=EBI |
| _version_ | 1818701202243715072 |
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| author | Peter Willeit Alexander Thompson Thor Aspelund Ann Rumley Gudny Eiriksdottir Gordon Lowe Vilmundur Gudnason Emanuele Di Angelantonio |
| author_facet | Peter Willeit Alexander Thompson Thor Aspelund Ann Rumley Gudny Eiriksdottir Gordon Lowe Vilmundur Gudnason Emanuele Di Angelantonio |
| author_sort | Peter Willeit |
| collection | DOAJ |
| description | <h4>Background</h4>Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk.<h4>Design</h4>Prospective case-control study, systematic review and meta-analyses.<h4>Methods</h4>Measurements were made in 1925 people who had a first-ever nonfatal myocardial infarction or died of coronary heart disease during follow-up (median 19.4 years) and in 3616 controls nested within the prospective population-based Reykjavik Study.<h4>Results</h4>Age and sex-adjusted odds ratios for coronary heart disease per 1 standard deviation higher baseline level were 1.25 (1.18, 1.33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF. After additional adjustment for conventional cardiovascular risk factors, corresponding odds ratios were 1.07 (0.99, 1.14) for t-PA antigen, 1.06 (1.00, 1.13) for D-dimer and 1.08 (1.02, 1.15) for VWF. When combined with the results from previous prospective studies in a random-effects meta-analysis, overall adjusted odds ratios were 1.13 (1.06, 1.21) for t-PA antigen (13 studies, 5494 cases), 1.23 (1.16, 1.32) with D-dimer (18 studies, 6799 cases) and 1.16 (1.10, 1.22) with VWF (15 studies, 6556 cases).<h4>Conclusions</h4>Concentrations of t-PA antigen, D-dimer and VWF may be more modestly associated with first-ever CHD events than previously reported. More detailed analysis is required to clarify whether these markers are causal risk factors or simply correlates of coronary heart disease. |
| first_indexed | 2024-12-17T15:17:05Z |
| format | Article |
| id | doaj.art-77db2959f564416e85ae5c7b5b8aa9c8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:17:05Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-77db2959f564416e85ae5c7b5b8aa9c82022-12-21T21:43:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5517510.1371/journal.pone.0055175Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses.Peter WilleitAlexander ThompsonThor AspelundAnn RumleyGudny EiriksdottirGordon LoweVilmundur GudnasonEmanuele Di Angelantonio<h4>Background</h4>Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk.<h4>Design</h4>Prospective case-control study, systematic review and meta-analyses.<h4>Methods</h4>Measurements were made in 1925 people who had a first-ever nonfatal myocardial infarction or died of coronary heart disease during follow-up (median 19.4 years) and in 3616 controls nested within the prospective population-based Reykjavik Study.<h4>Results</h4>Age and sex-adjusted odds ratios for coronary heart disease per 1 standard deviation higher baseline level were 1.25 (1.18, 1.33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF. After additional adjustment for conventional cardiovascular risk factors, corresponding odds ratios were 1.07 (0.99, 1.14) for t-PA antigen, 1.06 (1.00, 1.13) for D-dimer and 1.08 (1.02, 1.15) for VWF. When combined with the results from previous prospective studies in a random-effects meta-analysis, overall adjusted odds ratios were 1.13 (1.06, 1.21) for t-PA antigen (13 studies, 5494 cases), 1.23 (1.16, 1.32) with D-dimer (18 studies, 6799 cases) and 1.16 (1.10, 1.22) with VWF (15 studies, 6556 cases).<h4>Conclusions</h4>Concentrations of t-PA antigen, D-dimer and VWF may be more modestly associated with first-ever CHD events than previously reported. More detailed analysis is required to clarify whether these markers are causal risk factors or simply correlates of coronary heart disease.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23408959/pdf/?tool=EBI |
| spellingShingle | Peter Willeit Alexander Thompson Thor Aspelund Ann Rumley Gudny Eiriksdottir Gordon Lowe Vilmundur Gudnason Emanuele Di Angelantonio Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. PLoS ONE |
| title | Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. |
| title_full | Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. |
| title_fullStr | Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. |
| title_full_unstemmed | Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. |
| title_short | Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses. |
| title_sort | hemostatic factors and risk of coronary heart disease in general populations new prospective study and updated meta analyses |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23408959/pdf/?tool=EBI |
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