The effect of Nigella sativa on learning and memory in male diabetic rats
Abstract Introduction: Diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Considering the beneficial antidiabetic potential of Nigella sativum (NS ), this research study was conducted to evaluate the effect of ch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2009-01-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-8&slc_lang=en&sid=1 |
| _version_ | 1797283799725244416 |
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| author | Mohammad reza Jalali nodoushan Mehrdad Roghani |
| author_facet | Mohammad reza Jalali nodoushan Mehrdad Roghani |
| author_sort | Mohammad reza Jalali nodoushan |
| collection | DOAJ |
| description | Abstract Introduction: Diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Considering the beneficial antidiabetic potential of Nigella sativum (NS ), this research study was conducted to evaluate the effect of chronic consumption of NS on learning and memory in diabetic rats using passive avoidance and Y-maze tests. Methods: Male Wistar rats were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. NS treatment continued for 1 month. For induction of diabetes, streptozotocin was injected i.p. at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of study using passive avoidance test. Meanwhile, alternation behavior percentage was determined using Y maze. Results: There was a significant increase (p<0.05) in IL in diabetic and NS-treated diabetic groups after 4 weeks as compared to control group. In this respect, there was no significant difference between diabetic and NS-treated diabetic groups. On the other hand, STL significantly decreased (p<0.05) in diabetic group and significantly increased (p<0.01) in NS-treated diabetic group as compared to control group at the end of study. In addition, results of Y-maze test showed that there is a significant difference between diabetic and NS-treated diabetic groups (p<0.05) regarding alternation behavior. Discussion: In summary, chronic oral administration of NS could enhance the consolidation and recall capability of stored information and spatial memory in diabetic animals. |
| first_indexed | 2024-03-07T17:37:03Z |
| format | Article |
| id | doaj.art-77de701e39884ad2a24dd9a80880df5d |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:37:03Z |
| publishDate | 2009-01-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-77de701e39884ad2a24dd9a80880df5d2024-03-02T16:44:45ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422009-01-01113234The effect of Nigella sativa on learning and memory in male diabetic ratsMohammad reza Jalali nodoushanMehrdad RoghaniAbstract Introduction: Diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Considering the beneficial antidiabetic potential of Nigella sativum (NS ), this research study was conducted to evaluate the effect of chronic consumption of NS on learning and memory in diabetic rats using passive avoidance and Y-maze tests. Methods: Male Wistar rats were randomly divided into control, NS-treated control, diabetic, and NS-treated diabetic groups. NS treatment continued for 1 month. For induction of diabetes, streptozotocin was injected i.p. at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of study using passive avoidance test. Meanwhile, alternation behavior percentage was determined using Y maze. Results: There was a significant increase (p<0.05) in IL in diabetic and NS-treated diabetic groups after 4 weeks as compared to control group. In this respect, there was no significant difference between diabetic and NS-treated diabetic groups. On the other hand, STL significantly decreased (p<0.05) in diabetic group and significantly increased (p<0.01) in NS-treated diabetic group as compared to control group at the end of study. In addition, results of Y-maze test showed that there is a significant difference between diabetic and NS-treated diabetic groups (p<0.05) regarding alternation behavior. Discussion: In summary, chronic oral administration of NS could enhance the consolidation and recall capability of stored information and spatial memory in diabetic animals.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-8&slc_lang=en&sid=1Nigella sativumLearningMemoryDiabetes Mellitus |
| spellingShingle | Mohammad reza Jalali nodoushan Mehrdad Roghani The effect of Nigella sativa on learning and memory in male diabetic rats Basic and Clinical Neuroscience Nigella sativum Learning Memory Diabetes Mellitus |
| title | The effect of Nigella sativa on learning and memory in male diabetic rats |
| title_full | The effect of Nigella sativa on learning and memory in male diabetic rats |
| title_fullStr | The effect of Nigella sativa on learning and memory in male diabetic rats |
| title_full_unstemmed | The effect of Nigella sativa on learning and memory in male diabetic rats |
| title_short | The effect of Nigella sativa on learning and memory in male diabetic rats |
| title_sort | effect of nigella sativa on learning and memory in male diabetic rats |
| topic | Nigella sativum Learning Memory Diabetes Mellitus |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-8&slc_lang=en&sid=1 |
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