Sample Size Reassessment and Hypothesis Testing in Adaptive Survival Trials.
Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled. It is therefore unfortunate that the important case of time-to-event endpoints is not easily handled by the standard the...
Main Authors: | Dominic Magirr, Thomas Jaki, Franz Koenig, Martin Posch |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4749572?pdf=render |
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