Nanoparticles for Ferroptosis Therapy in Cancer
Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/11/1785 |
| _version_ | 1797508801193050112 |
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| author | Nadia Zaffaroni Giovanni Luca Beretta |
| author_facet | Nadia Zaffaroni Giovanni Luca Beretta |
| author_sort | Nadia Zaffaroni |
| collection | DOAJ |
| description | Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy. |
| first_indexed | 2024-03-10T05:09:02Z |
| format | Article |
| id | doaj.art-77e10f2cd58842fdaa46bd22e0040462 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:09:02Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-77e10f2cd58842fdaa46bd22e00404622023-11-23T00:57:34ZengMDPI AGPharmaceutics1999-49232021-10-011311178510.3390/pharmaceutics13111785Nanoparticles for Ferroptosis Therapy in CancerNadia Zaffaroni0Giovanni Luca Beretta1Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyMolecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, ItalyFerroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy.https://www.mdpi.com/1999-4923/13/11/1785ferroptosisnanoparticlescancertumor targetingiron |
| spellingShingle | Nadia Zaffaroni Giovanni Luca Beretta Nanoparticles for Ferroptosis Therapy in Cancer Pharmaceutics ferroptosis nanoparticles cancer tumor targeting iron |
| title | Nanoparticles for Ferroptosis Therapy in Cancer |
| title_full | Nanoparticles for Ferroptosis Therapy in Cancer |
| title_fullStr | Nanoparticles for Ferroptosis Therapy in Cancer |
| title_full_unstemmed | Nanoparticles for Ferroptosis Therapy in Cancer |
| title_short | Nanoparticles for Ferroptosis Therapy in Cancer |
| title_sort | nanoparticles for ferroptosis therapy in cancer |
| topic | ferroptosis nanoparticles cancer tumor targeting iron |
| url | https://www.mdpi.com/1999-4923/13/11/1785 |
| work_keys_str_mv | AT nadiazaffaroni nanoparticlesforferroptosistherapyincancer AT giovannilucaberetta nanoparticlesforferroptosistherapyincancer |