Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine
The global burden of cancer continues to rise, underscoring the urgency of developing more effective and precisely targeted therapies. This comprehensive review explores the confluence of precision medicine and CDC25 phosphatases in the context of cancer research. Precision medicine, alternatively r...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1324001/full |
| _version_ | 1827378812110766080 |
|---|---|
| author | Ibraheem Dakilah Amani Harb Eman Abu-Gharbieh Eman Abu-Gharbieh Waseem El-Huneidi Waseem El-Huneidi Jalal Taneera Jalal Taneera Rifat Hamoudi Rifat Hamoudi Rifat Hamoudi Mohammed H. Semreen Yasser Bustanji Yasser Bustanji Yasser Bustanji |
| author_facet | Ibraheem Dakilah Amani Harb Eman Abu-Gharbieh Eman Abu-Gharbieh Waseem El-Huneidi Waseem El-Huneidi Jalal Taneera Jalal Taneera Rifat Hamoudi Rifat Hamoudi Rifat Hamoudi Mohammed H. Semreen Yasser Bustanji Yasser Bustanji Yasser Bustanji |
| author_sort | Ibraheem Dakilah |
| collection | DOAJ |
| description | The global burden of cancer continues to rise, underscoring the urgency of developing more effective and precisely targeted therapies. This comprehensive review explores the confluence of precision medicine and CDC25 phosphatases in the context of cancer research. Precision medicine, alternatively referred to as customized medicine, aims to customize medical interventions by taking into account the genetic, genomic, and epigenetic characteristics of individual patients. The identification of particular genetic and molecular drivers driving cancer helps both diagnostic accuracy and treatment selection. Precision medicine utilizes sophisticated technology such as genome sequencing and bioinformatics to elucidate genetic differences that underlie the proliferation of cancer cells, hence facilitating the development of customized therapeutic interventions. CDC25 phosphatases, which play a crucial role in governing the progression of the cell cycle, have garnered significant attention as potential targets for cancer treatment. The dysregulation of CDC25 is a characteristic feature observed in various types of malignancies, hence classifying them as proto-oncogenes. The proteins in question, which operate as phosphatases, play a role in the activation of Cyclin-dependent kinases (CDKs), so promoting the advancement of the cell cycle. CDC25 inhibitors demonstrate potential as therapeutic drugs for cancer treatment by specifically blocking the activity of CDKs and modulating the cell cycle in malignant cells. In brief, precision medicine presents a potentially fruitful option for augmenting cancer research, diagnosis, and treatment, with an emphasis on individualized care predicated upon patients’ genetic and molecular profiles. The review highlights the significance of CDC25 phosphatases in the advancement of cancer and identifies them as promising candidates for therapeutic intervention. This statement underscores the significance of doing thorough molecular profiling in order to uncover the complex molecular characteristics of cancer cells. |
| first_indexed | 2024-03-08T13:02:17Z |
| format | Article |
| id | doaj.art-77e20f72898440a3aa4de4fb1de396b6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T13:02:17Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-77e20f72898440a3aa4de4fb1de396b62024-01-19T04:42:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-01-011510.3389/fphar.2024.13240011324001Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicineIbraheem Dakilah0Amani Harb1Eman Abu-Gharbieh2Eman Abu-Gharbieh3Waseem El-Huneidi4Waseem El-Huneidi5Jalal Taneera6Jalal Taneera7Rifat Hamoudi8Rifat Hamoudi9Rifat Hamoudi10Mohammed H. Semreen11Yasser Bustanji12Yasser Bustanji13Yasser Bustanji14Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesDepartment of Basic Sciences, Faculty of Arts and Sciences, Al-Ahliyya Amman University, Amman, JordanResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesDivision of Surgery and Interventional Science, University College London, London, United KingdomCollege of Pharmacy, University of Sharjah, Sharjah, United Arab EmiratesResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah, United Arab EmiratesCollege of Medicine, University of Sharjah, Sharjah, United Arab EmiratesSchool of Pharmacy, The University of Jordan, Amman, JordanThe global burden of cancer continues to rise, underscoring the urgency of developing more effective and precisely targeted therapies. This comprehensive review explores the confluence of precision medicine and CDC25 phosphatases in the context of cancer research. Precision medicine, alternatively referred to as customized medicine, aims to customize medical interventions by taking into account the genetic, genomic, and epigenetic characteristics of individual patients. The identification of particular genetic and molecular drivers driving cancer helps both diagnostic accuracy and treatment selection. Precision medicine utilizes sophisticated technology such as genome sequencing and bioinformatics to elucidate genetic differences that underlie the proliferation of cancer cells, hence facilitating the development of customized therapeutic interventions. CDC25 phosphatases, which play a crucial role in governing the progression of the cell cycle, have garnered significant attention as potential targets for cancer treatment. The dysregulation of CDC25 is a characteristic feature observed in various types of malignancies, hence classifying them as proto-oncogenes. The proteins in question, which operate as phosphatases, play a role in the activation of Cyclin-dependent kinases (CDKs), so promoting the advancement of the cell cycle. CDC25 inhibitors demonstrate potential as therapeutic drugs for cancer treatment by specifically blocking the activity of CDKs and modulating the cell cycle in malignant cells. In brief, precision medicine presents a potentially fruitful option for augmenting cancer research, diagnosis, and treatment, with an emphasis on individualized care predicated upon patients’ genetic and molecular profiles. The review highlights the significance of CDC25 phosphatases in the advancement of cancer and identifies them as promising candidates for therapeutic intervention. This statement underscores the significance of doing thorough molecular profiling in order to uncover the complex molecular characteristics of cancer cells.https://www.frontiersin.org/articles/10.3389/fphar.2024.1324001/fullcancerCDC25natural compoundsAI (artificial intelligence)precision medicineomics |
| spellingShingle | Ibraheem Dakilah Amani Harb Eman Abu-Gharbieh Eman Abu-Gharbieh Waseem El-Huneidi Waseem El-Huneidi Jalal Taneera Jalal Taneera Rifat Hamoudi Rifat Hamoudi Rifat Hamoudi Mohammed H. Semreen Yasser Bustanji Yasser Bustanji Yasser Bustanji Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine Frontiers in Pharmacology cancer CDC25 natural compounds AI (artificial intelligence) precision medicine omics |
| title | Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine |
| title_full | Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine |
| title_fullStr | Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine |
| title_full_unstemmed | Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine |
| title_short | Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine |
| title_sort | potential of cdc25 phosphatases in cancer research and treatment key to precision medicine |
| topic | cancer CDC25 natural compounds AI (artificial intelligence) precision medicine omics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1324001/full |
| work_keys_str_mv | AT ibraheemdakilah potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT amaniharb potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT emanabugharbieh potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT emanabugharbieh potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT waseemelhuneidi potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT waseemelhuneidi potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT jalaltaneera potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT jalaltaneera potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT rifathamoudi potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT rifathamoudi potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT rifathamoudi potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT mohammedhsemreen potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT yasserbustanji potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT yasserbustanji potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine AT yasserbustanji potentialofcdc25phosphatasesincancerresearchandtreatmentkeytoprecisionmedicine |