Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components
FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane. Here, we define the minimal molecular machinery required for FGF2 membrane translocation in a fully reconstituted inside-out vesicle system. FGF2 membrane...
Main Authors: | Julia P Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/28985 |
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