Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids
Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents. Over the years, a large number of protein kinase inhibitors have been discovered and developed as anti...
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| Format: | Article |
| Language: | English |
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IMR Press
2021-11-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/26/11/10.52586/5028 |
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| author | Hanlin Ye Linlin Wang Li Ma Maksim Ionov Gan Qiao Jianlin Huang Li Cheng Yuxi Zhang Xiaohui Yang Shousong Cao Xiukun Lin |
| author_facet | Hanlin Ye Linlin Wang Li Ma Maksim Ionov Gan Qiao Jianlin Huang Li Cheng Yuxi Zhang Xiaohui Yang Shousong Cao Xiukun Lin |
| author_sort | Hanlin Ye |
| collection | DOAJ |
| description | Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents. Over the years, a large number of protein kinase inhibitors have been discovered and developed as anticancer agents for the treatment of cancers clinically. However, the drug-resiatance and off-targeting limit their effeciancy for the treatment of human cancer. Materials and methods: Alkaloids are an important class of natural products with broad spectrum biological activities. In the past decades, numerus alkaloids with significant anticancer activity by inhibiting protein kinases were identified. In the present mini-review, we will present the key enzymes including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and janus-activated kinases/signal transducer and activator of transcription (JAK/STAT) targeted by alkaloids and highlight the special sites targeted by alkaloids on protein kinases and/or reversing drug resistance. Additionally, the challenge and prospect of developing alkaloids as new anticancer agents are also discussed. Conclusion: Alkaloids suppressed tumor growth through targeting different signaling pathways mediated by protein kinases of cancer cells. It is conceivable that novel alkaloids anticancer agents with promising clinical value will be developed in the future. |
| first_indexed | 2024-12-21T10:50:56Z |
| format | Article |
| id | doaj.art-77e2835dda7b4a88a4cf04e1ecbb80c9 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-21T10:50:56Z |
| publishDate | 2021-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-77e2835dda7b4a88a4cf04e1ecbb80c92022-12-21T19:06:40ZengIMR PressFrontiers in Bioscience-Landmark2768-67012021-11-0126111349136110.52586/5028s2768-6701(21)00075-7Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloidsHanlin Ye0Linlin Wang1Li Ma2Maksim Ionov3Gan Qiao4Jianlin Huang5Li Cheng6Yuxi Zhang7Xiaohui Yang8Shousong Cao9Xiukun Lin10Department of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaRizhao Hospital of Traditional Chinese Medicine, 276826 Rizhao, Shandong, ChinaDepartment of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaDepartment of Pharmacology, School of Pharmacy, Southwest Medical University, 646000 Luzhou, Sichuan, ChinaBackgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents. Over the years, a large number of protein kinase inhibitors have been discovered and developed as anticancer agents for the treatment of cancers clinically. However, the drug-resiatance and off-targeting limit their effeciancy for the treatment of human cancer. Materials and methods: Alkaloids are an important class of natural products with broad spectrum biological activities. In the past decades, numerus alkaloids with significant anticancer activity by inhibiting protein kinases were identified. In the present mini-review, we will present the key enzymes including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and janus-activated kinases/signal transducer and activator of transcription (JAK/STAT) targeted by alkaloids and highlight the special sites targeted by alkaloids on protein kinases and/or reversing drug resistance. Additionally, the challenge and prospect of developing alkaloids as new anticancer agents are also discussed. Conclusion: Alkaloids suppressed tumor growth through targeting different signaling pathways mediated by protein kinases of cancer cells. It is conceivable that novel alkaloids anticancer agents with promising clinical value will be developed in the future.https://www.imrpress.com/journal/FBL/26/11/10.52586/5028alkaloidsprotein kinase inhibitorsanticancer activitymapkpi3k/akt/mtorjak/stat |
| spellingShingle | Hanlin Ye Linlin Wang Li Ma Maksim Ionov Gan Qiao Jianlin Huang Li Cheng Yuxi Zhang Xiaohui Yang Shousong Cao Xiukun Lin Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids Frontiers in Bioscience-Landmark alkaloids protein kinase inhibitors anticancer activity mapk pi3k/akt/mtor jak/stat |
| title | Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids |
| title_full | Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids |
| title_fullStr | Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids |
| title_full_unstemmed | Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids |
| title_short | Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids |
| title_sort | protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids |
| topic | alkaloids protein kinase inhibitors anticancer activity mapk pi3k/akt/mtor jak/stat |
| url | https://www.imrpress.com/journal/FBL/26/11/10.52586/5028 |
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