Discovery of novel diarylamides as orally active diuretics targeting urea transporters

Discovery of novel diarylamides as orally active diuretics targeting urea transporters

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In the present study, a novel UT inhibitor with a diarylamide scaf...

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Bibliographic Details
Main Authors: Shun Zhang, Yan Zhao, Shuyuan Wang, Min Li, Yue Xu, Jianhua Ran, Xiaoqiang Geng, Jinzhao He, Jia Meng, Guangying Shao, Hong Zhou, Zemei Ge, Guangping Chen, Runtao Li, Baoxue Yang
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Urea transporter inhibitor
Diuretic
Structure optimization
Oral administration
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520305943

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