Gluco-metabolic effects of oral and intravenous alcohol administration in men
Background: Ingestion of the calorically dense compound alcohol may cause metabolic disturbances including hypoglycaemia, hepatic steatosis and insulin resistance, but the underlying mechanisms are uncertain. The gastrointestinal tract is well recognised as a major influencer on glucose, protein and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2019-10-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/8/10/EC-19-0317.xml |
| _version_ | 1818449566885740544 |
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| author | Amalie R Lanng Lærke S Gasbjerg Natasha C Bergmann Sigrid Bergmann Mads M Helsted Matthew P Gillum Bolette Hartmann Jens J Holst Tina Vilsbøll Filip K Knop |
| author_facet | Amalie R Lanng Lærke S Gasbjerg Natasha C Bergmann Sigrid Bergmann Mads M Helsted Matthew P Gillum Bolette Hartmann Jens J Holst Tina Vilsbøll Filip K Knop |
| author_sort | Amalie R Lanng |
| collection | DOAJ |
| description | Background: Ingestion of the calorically dense compound alcohol may cause metabolic disturbances including hypoglycaemia, hepatic steatosis and insulin resistance, but the underlying mechanisms are uncertain. The gastrointestinal tract is well recognised as a major influencer on glucose, protein and lipid metabolism, but its role in alcohol metabolism remains unclear.
Objective: To examine the effects of oral and intravenous alcohol, respect ively, on plasma concentrations of several gluco-regulatory hormones including serum/plasma insulin, C-peptide, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21).
Design and methods: In a double-blinded, randomised, crossover design, we subjected 12 healthy men to intragastric ethanol infusion (IGEI) and an isoethanolaemic intravenous ethanol infusion (IVEI) (0.7 g alcohol per kg body weight), res pectively, on two separate experimental days.
Results: Isoethanolaemia during the two alcohol administration forms was obtained (P = 0.38). During both interventions, plasma glucose peaked after ~30 min and thereafter fell below baseline concentrations. GIP and GLP-1 concentrations were unaffected by the two interventions. Insulin concentrations were unaffected by IGEI but decreased during IVEI. C-peptide, insulin secretion rate and glucagon concentrations were lowered similarly during IGEI and IVEI. FGF21 concentrations increased dramatically (nine-fold) and similarly during IGEI and IVEI.
Conclusions: Alcohol does not seem to affect the secretion of incretin hormo nes but decreased insulin and glucagon secretion independently of gut-derived factors. IGEI as well as IVEI potently stimulate FGF21 secretion indicating a gut-ind ependent effect of alcohol on FGF21 secretion in humans. |
| first_indexed | 2024-12-14T20:37:27Z |
| format | Article |
| id | doaj.art-77e570b02809446c96f4503abc47fc8c |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-14T20:37:27Z |
| publishDate | 2019-10-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-77e570b02809446c96f4503abc47fc8c2022-12-21T22:48:22ZengBioscientificaEndocrine Connections2049-36142049-36142019-10-0181013721382https://doi.org/10.1530/EC-19-0317Gluco-metabolic effects of oral and intravenous alcohol administration in menAmalie R Lanng0Lærke S Gasbjerg1Natasha C Bergmann2Sigrid Bergmann3Mads M Helsted4Matthew P Gillum5Bolette Hartmann6Jens J Holst7Tina Vilsbøll8Filip K Knop9Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkBackground: Ingestion of the calorically dense compound alcohol may cause metabolic disturbances including hypoglycaemia, hepatic steatosis and insulin resistance, but the underlying mechanisms are uncertain. The gastrointestinal tract is well recognised as a major influencer on glucose, protein and lipid metabolism, but its role in alcohol metabolism remains unclear. Objective: To examine the effects of oral and intravenous alcohol, respect ively, on plasma concentrations of several gluco-regulatory hormones including serum/plasma insulin, C-peptide, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and fibroblast growth factor 21 (FGF21). Design and methods: In a double-blinded, randomised, crossover design, we subjected 12 healthy men to intragastric ethanol infusion (IGEI) and an isoethanolaemic intravenous ethanol infusion (IVEI) (0.7 g alcohol per kg body weight), res pectively, on two separate experimental days. Results: Isoethanolaemia during the two alcohol administration forms was obtained (P = 0.38). During both interventions, plasma glucose peaked after ~30 min and thereafter fell below baseline concentrations. GIP and GLP-1 concentrations were unaffected by the two interventions. Insulin concentrations were unaffected by IGEI but decreased during IVEI. C-peptide, insulin secretion rate and glucagon concentrations were lowered similarly during IGEI and IVEI. FGF21 concentrations increased dramatically (nine-fold) and similarly during IGEI and IVEI. Conclusions: Alcohol does not seem to affect the secretion of incretin hormo nes but decreased insulin and glucagon secretion independently of gut-derived factors. IGEI as well as IVEI potently stimulate FGF21 secretion indicating a gut-ind ependent effect of alcohol on FGF21 secretion in humans.https://ec.bioscientifica.com/view/journals/ec/8/10/EC-19-0317.xmlalcoholFGF21glucoseglucagonincretin hormonesinsulin |
| spellingShingle | Amalie R Lanng Lærke S Gasbjerg Natasha C Bergmann Sigrid Bergmann Mads M Helsted Matthew P Gillum Bolette Hartmann Jens J Holst Tina Vilsbøll Filip K Knop Gluco-metabolic effects of oral and intravenous alcohol administration in men Endocrine Connections alcohol FGF21 glucose glucagon incretin hormones insulin |
| title | Gluco-metabolic effects of oral and intravenous alcohol administration in men |
| title_full | Gluco-metabolic effects of oral and intravenous alcohol administration in men |
| title_fullStr | Gluco-metabolic effects of oral and intravenous alcohol administration in men |
| title_full_unstemmed | Gluco-metabolic effects of oral and intravenous alcohol administration in men |
| title_short | Gluco-metabolic effects of oral and intravenous alcohol administration in men |
| title_sort | gluco metabolic effects of oral and intravenous alcohol administration in men |
| topic | alcohol FGF21 glucose glucagon incretin hormones insulin |
| url | https://ec.bioscientifica.com/view/journals/ec/8/10/EC-19-0317.xml |
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