Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer

Cysteine protease inhibitor 1 promotes metastasis by mediating an oxidative phosphorylation/MEK/ERK axis in esophageal squamous carcinoma cancer

Abstract Cysteine protease inhibitor 1 (CST1) is a cystatin superfamily protein that inhibits cysteine protease activity and is reported to be involved in the development of many malignancies. Mitochondrial oxidative phosphorylation (OXPHOS) also plays an important role in cancer cell growth regulat...

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Bibliographic Details
Main Authors: Liangming Zhang, Xiongfeng Chen, Jianwei Wang, Meihong Chen, Juan Chen, Wanzhen Zhuang, Yu Xia, Zhixin Huang, Yue Zheng, Yi Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
CST1
Esophageal squamous cell carcinoma
Oxidative phosphorylation
MEK/ERK pathway
Online Access:https://doi.org/10.1038/s41598-024-55544-1

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