Cancer functional states-based molecular subtypes of gastric cancer
Abstract Background The treatment of gastric cancer remains a challenge. Methods We divided gastric cancer into three subtypes based on 14 cancer functional states. We investigated differences between subtypes through multi-omics data, especially at the single-cell level, which allowed us to analyze...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-03921-1 |
| _version_ | 1811171570991759360 |
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| author | Qi Zhou Yiwu Yuan Hao Lu Xueqin Li Ziyang Liu Jinheng Gan Zhenqi Yue Jiping Wu Jie Sheng Lin Xin |
| author_facet | Qi Zhou Yiwu Yuan Hao Lu Xueqin Li Ziyang Liu Jinheng Gan Zhenqi Yue Jiping Wu Jie Sheng Lin Xin |
| author_sort | Qi Zhou |
| collection | DOAJ |
| description | Abstract Background The treatment of gastric cancer remains a challenge. Methods We divided gastric cancer into three subtypes based on 14 cancer functional states. We investigated differences between subtypes through multi-omics data, especially at the single-cell level, which allowed us to analyze differences from the perspective of each type of cell rather than the whole. Results The cluster 1 is characterized by high levels of tumor progression-related cancer functional status, worst survival outcomes, low metabolic level, high infiltration of immunosuppressive cells, high copy number variations (CNV), and low tumor mutational burden (TMB). The cluster 2 is characterized by low levels of tumor progression-related cancer functional status, favorable prognosis, moderate metabolic level, low immune cell infiltration, high CNV, and moderate TMB. Then, the cluster 3 is characterized by the high level of all cancer functional status, high metabolic level, low CNV, high TMB, high infiltration of immune cells with high cytotoxicity, and better response to immunotherapy. We also established a prognostic model based on cancer functional status and validated its robustness. Conclusions Collectively, our study identified gastric cancer subtypes and provided new insights into the clinical treatment of gastric cancer. |
| first_indexed | 2024-04-10T17:16:15Z |
| format | Article |
| id | doaj.art-77e699ac388b40afad21df62daba6997 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-10T17:16:15Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-77e699ac388b40afad21df62daba69972023-02-05T12:22:18ZengBMCJournal of Translational Medicine1479-58762023-02-0121111510.1186/s12967-023-03921-1Cancer functional states-based molecular subtypes of gastric cancerQi Zhou0Yiwu Yuan1Hao Lu2Xueqin Li3Ziyang Liu4Jinheng Gan5Zhenqi Yue6Jiping Wu7Jie Sheng8Lin Xin9Department of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of General Surgery, The Second Affiliated Hospital of Nanchang UniversityAbstract Background The treatment of gastric cancer remains a challenge. Methods We divided gastric cancer into three subtypes based on 14 cancer functional states. We investigated differences between subtypes through multi-omics data, especially at the single-cell level, which allowed us to analyze differences from the perspective of each type of cell rather than the whole. Results The cluster 1 is characterized by high levels of tumor progression-related cancer functional status, worst survival outcomes, low metabolic level, high infiltration of immunosuppressive cells, high copy number variations (CNV), and low tumor mutational burden (TMB). The cluster 2 is characterized by low levels of tumor progression-related cancer functional status, favorable prognosis, moderate metabolic level, low immune cell infiltration, high CNV, and moderate TMB. Then, the cluster 3 is characterized by the high level of all cancer functional status, high metabolic level, low CNV, high TMB, high infiltration of immune cells with high cytotoxicity, and better response to immunotherapy. We also established a prognostic model based on cancer functional status and validated its robustness. Conclusions Collectively, our study identified gastric cancer subtypes and provided new insights into the clinical treatment of gastric cancer.https://doi.org/10.1186/s12967-023-03921-1Gastric cancerCancer functional statesSubtypesSingle cell |
| spellingShingle | Qi Zhou Yiwu Yuan Hao Lu Xueqin Li Ziyang Liu Jinheng Gan Zhenqi Yue Jiping Wu Jie Sheng Lin Xin Cancer functional states-based molecular subtypes of gastric cancer Journal of Translational Medicine Gastric cancer Cancer functional states Subtypes Single cell |
| title | Cancer functional states-based molecular subtypes of gastric cancer |
| title_full | Cancer functional states-based molecular subtypes of gastric cancer |
| title_fullStr | Cancer functional states-based molecular subtypes of gastric cancer |
| title_full_unstemmed | Cancer functional states-based molecular subtypes of gastric cancer |
| title_short | Cancer functional states-based molecular subtypes of gastric cancer |
| title_sort | cancer functional states based molecular subtypes of gastric cancer |
| topic | Gastric cancer Cancer functional states Subtypes Single cell |
| url | https://doi.org/10.1186/s12967-023-03921-1 |
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