Alzheimer’s disease as an inflammatory disease
Alzheimer’s disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-02-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2016-0029 |
| _version_ | 1811159435822759936 |
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| author | Bolós Marta Perea Juan Ramón Avila Jesús |
| author_facet | Bolós Marta Perea Juan Ramón Avila Jesús |
| author_sort | Bolós Marta |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration. |
| first_indexed | 2024-04-10T05:41:05Z |
| format | Article |
| id | doaj.art-77ea4adf46294e9891b83d695005b723 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-04-10T05:41:05Z |
| publishDate | 2017-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-77ea4adf46294e9891b83d695005b7232023-03-06T10:24:51ZengDe GruyterBiomolecular Concepts1868-50211868-503X2017-02-0181374310.1515/bmc-2016-0029Alzheimer’s disease as an inflammatory diseaseBolós Marta0Perea Juan Ramón1Avila Jesús2Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo 5, E-28041-Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo 5, E-28041-Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Valderrebollo 5, E-28041-Madrid, SpainAlzheimer’s disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.https://doi.org/10.1515/bmc-2016-0029alzheimer’s diseasebeta amyloid peptide (aβ)inflammationmicrogliatau |
| spellingShingle | Bolós Marta Perea Juan Ramón Avila Jesús Alzheimer’s disease as an inflammatory disease Biomolecular Concepts alzheimer’s disease beta amyloid peptide (aβ) inflammation microglia tau |
| title | Alzheimer’s disease as an inflammatory disease |
| title_full | Alzheimer’s disease as an inflammatory disease |
| title_fullStr | Alzheimer’s disease as an inflammatory disease |
| title_full_unstemmed | Alzheimer’s disease as an inflammatory disease |
| title_short | Alzheimer’s disease as an inflammatory disease |
| title_sort | alzheimer s disease as an inflammatory disease |
| topic | alzheimer’s disease beta amyloid peptide (aβ) inflammation microglia tau |
| url | https://doi.org/10.1515/bmc-2016-0029 |
| work_keys_str_mv | AT bolosmarta alzheimersdiseaseasaninflammatorydisease AT pereajuanramon alzheimersdiseaseasaninflammatorydisease AT avilajesus alzheimersdiseaseasaninflammatorydisease |