Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, progressive inflammatory and systemic autoimmune disease resulting in severe joint destruction, lifelong suffering and considerable disability. Diverse prescriptions of traditional Chinese medicine (TCM) containing Epimedii Herba (EH) achieve greatly curative...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1023779/full |
| _version_ | 1797988358466568192 |
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| author | Liu-Bo Zhang Liu-Bo Zhang Yu Yan Jun He Pei-Pei Wang Xin Chen Tian-Yi Lan Tian-Yi Lan Yu-Xuan Guo Yu-Xuan Guo Jin-Ping Wang Jing Luo Ze-Ran Yan Yuan Xu Qing-Wen Tao |
| author_facet | Liu-Bo Zhang Liu-Bo Zhang Yu Yan Jun He Pei-Pei Wang Xin Chen Tian-Yi Lan Tian-Yi Lan Yu-Xuan Guo Yu-Xuan Guo Jin-Ping Wang Jing Luo Ze-Ran Yan Yuan Xu Qing-Wen Tao |
| author_sort | Liu-Bo Zhang |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic, progressive inflammatory and systemic autoimmune disease resulting in severe joint destruction, lifelong suffering and considerable disability. Diverse prescriptions of traditional Chinese medicine (TCM) containing Epimedii Herba (EH) achieve greatly curative effects against RA. The present review aims to systemically summarize the therapeutic effect, pharmacological mechanism, bioavailability and safety assessment of EH to provide a novel insight for subsequent studies. The search terms included were “Epimedii Herba”, “yinyanghuo”, “arthritis, rheumatoid” and “Rheumatoid Arthritis”, and relevant literatures were collected on the database such as Google Scholar, Pubmed, Web of Science and CNKI. In this review, 15 compounds from EH for the treatment of RA were summarized from the aspects of anti-inflammatory, immunoregulatory, cartilage and bone protective, antiangiogenic and antioxidant activities. Although EH has been frequently used to treat RA in clinical practice, studies on mechanisms of these activities are still scarce. Various compounds of EH have the multifunctional traits in the treatment of RA, so EH may be a great complementary medicine option and it is necessary to pay more attention to further research and development. |
| first_indexed | 2024-04-11T08:01:27Z |
| format | Article |
| id | doaj.art-77ed38f99b17440a83e2fad80e8d0e67 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T08:01:27Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-77ed38f99b17440a83e2fad80e8d0e672022-12-22T04:35:42ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-11-011010.3389/fchem.2022.10237791023779Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritisLiu-Bo Zhang0Liu-Bo Zhang1Yu Yan2Jun He3Pei-Pei Wang4Xin Chen5Tian-Yi Lan6Tian-Yi Lan7Yu-Xuan Guo8Yu-Xuan Guo9Jin-Ping Wang10Jing Luo11Ze-Ran Yan12Yuan Xu13Qing-Wen Tao14Department of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaChina-Japan Friendship Clinical Medical College & School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaChina-Japan Friendship Clinical Medical College & School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaChina-Japan Friendship Clinical Medical College & School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaChina-Japan Friendship Clinical Medical College & School of Life Sciences, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaDepartment of TCM Rheumatism, Department of Pharmacy, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, ChinaRheumatoid arthritis (RA) is a chronic, progressive inflammatory and systemic autoimmune disease resulting in severe joint destruction, lifelong suffering and considerable disability. Diverse prescriptions of traditional Chinese medicine (TCM) containing Epimedii Herba (EH) achieve greatly curative effects against RA. The present review aims to systemically summarize the therapeutic effect, pharmacological mechanism, bioavailability and safety assessment of EH to provide a novel insight for subsequent studies. The search terms included were “Epimedii Herba”, “yinyanghuo”, “arthritis, rheumatoid” and “Rheumatoid Arthritis”, and relevant literatures were collected on the database such as Google Scholar, Pubmed, Web of Science and CNKI. In this review, 15 compounds from EH for the treatment of RA were summarized from the aspects of anti-inflammatory, immunoregulatory, cartilage and bone protective, antiangiogenic and antioxidant activities. Although EH has been frequently used to treat RA in clinical practice, studies on mechanisms of these activities are still scarce. Various compounds of EH have the multifunctional traits in the treatment of RA, so EH may be a great complementary medicine option and it is necessary to pay more attention to further research and development.https://www.frontiersin.org/articles/10.3389/fchem.2022.1023779/fullEpimedii Herbarheumatoid arthritispharmacologybioavailabilitytoxicity |
| spellingShingle | Liu-Bo Zhang Liu-Bo Zhang Yu Yan Jun He Pei-Pei Wang Xin Chen Tian-Yi Lan Tian-Yi Lan Yu-Xuan Guo Yu-Xuan Guo Jin-Ping Wang Jing Luo Ze-Ran Yan Yuan Xu Qing-Wen Tao Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis Frontiers in Chemistry Epimedii Herba rheumatoid arthritis pharmacology bioavailability toxicity |
| title | Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis |
| title_full | Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis |
| title_fullStr | Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis |
| title_full_unstemmed | Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis |
| title_short | Epimedii Herba: An ancient Chinese herbal medicine in the prevention and treatment of rheumatoid arthritis |
| title_sort | epimedii herba an ancient chinese herbal medicine in the prevention and treatment of rheumatoid arthritis |
| topic | Epimedii Herba rheumatoid arthritis pharmacology bioavailability toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1023779/full |
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