Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
Systemic sclerosis (SSc) disease involves multisystem fibrosis and autoimmunity with limited treatment options. Here the authors demonstrate that IL-31 and IL-31RA are overexpressed in dermal fibroblasts from SSc patients and show that fibrosis and cytokine release can be reduced upon blocking of IL...
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Bibliographic Details
| Main Authors: |
Ai Kuzumi,
Ayumi Yoshizaki,
Kazuki M. Matsuda,
Hirohito Kotani,
Yuta Norimatsu,
Maiko Fukayama,
Satoshi Ebata,
Takemichi Fukasawa,
Asako Yoshizaki-Ogawa,
Yoshihide Asano,
Kyojiro Morikawa,
Yutaka Kazoe,
Kazuma Mawatari,
Takehiko Kitamori,
Shinichi Sato |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26099-w
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