Association of cognitive enhancers and incident seizure risk in dementia: a population-based study
Abstract Background Although individuals with dementia have a high risk of developing seizures, whether seizures are associated with cholinesterase inhibitors, which are commonly prescribed to treat individuals with dementia, remains unknown. This study investigated the risk of incident seizure foll...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03120-5 |
| _version_ | 1828330217951723520 |
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| author | Junghee Ha Nak-Hoon Son Young Ho Park Eun Lee Eosu Kim Woo Jung Kim |
| author_facet | Junghee Ha Nak-Hoon Son Young Ho Park Eun Lee Eosu Kim Woo Jung Kim |
| author_sort | Junghee Ha |
| collection | DOAJ |
| description | Abstract Background Although individuals with dementia have a high risk of developing seizures, whether seizures are associated with cholinesterase inhibitors, which are commonly prescribed to treat individuals with dementia, remains unknown. This study investigated the risk of incident seizure following cholinesterase inhibitor use in patients with dementia. Methods A nationwide, nested case-control study was conducted using data from the Korean Health Insurance Review and Assessment Service (HIRA) from 2014 through 2018. A total of 13,767 participants aged 65–95 years who experienced incident seizure were propensity score-matched for medical comorbidities and drug exposure at a 1:3 ratio with a control group of 39,084 participants. The study examined the incidence of seizures in patients diagnosed with dementia within one year after receiving cognitive enhancers. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for seizure incidence according to cholinesterase inhibitor use were analyzed using a multivariable conditional logistic regression model. Results There was no statistically significant association between duration of cholinesterase inhibitors use and seizure risk. Although there was slight increased seizure risk in patient after receiving donepezil for 1 year compared to memantine, subgroup analyses stratified age and sex did not reveal any significant association between cholinesterase inhibitors use and late-onset seizure. Conclusions Our findings suggest no immediate increase in seizure risk is associated with cholinesterase inhibitor use, although the risk of seizure in patients with dementia did increase after one year of continued medication intake. Further study is required to obtain confirmatory results on the seizure-related safety of cognitive enhancers in patients with dementia. |
| first_indexed | 2024-04-13T20:37:04Z |
| format | Article |
| id | doaj.art-77ee0a92e984476a9033dbfea9dfa9b3 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-13T20:37:04Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-77ee0a92e984476a9033dbfea9dfa9b32022-12-22T02:31:01ZengBMCBMC Geriatrics1471-23182022-06-012211910.1186/s12877-022-03120-5Association of cognitive enhancers and incident seizure risk in dementia: a population-based studyJunghee Ha0Nak-Hoon Son1Young Ho Park2Eun Lee3Eosu Kim4Woo Jung Kim5Department of Psychiatry, Severance Hospital, Yonsei University College of MedicineDepartment of Statistics, Keimyung UniversityDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of MedicineDepartment of Psychiatry, Severance Hospital, Yonsei University College of MedicineDepartment of Psychiatry, Severance Hospital, Yonsei University College of MedicineInstitute of Behavioral Science in Medicine, Yonsei University College of MedicineAbstract Background Although individuals with dementia have a high risk of developing seizures, whether seizures are associated with cholinesterase inhibitors, which are commonly prescribed to treat individuals with dementia, remains unknown. This study investigated the risk of incident seizure following cholinesterase inhibitor use in patients with dementia. Methods A nationwide, nested case-control study was conducted using data from the Korean Health Insurance Review and Assessment Service (HIRA) from 2014 through 2018. A total of 13,767 participants aged 65–95 years who experienced incident seizure were propensity score-matched for medical comorbidities and drug exposure at a 1:3 ratio with a control group of 39,084 participants. The study examined the incidence of seizures in patients diagnosed with dementia within one year after receiving cognitive enhancers. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for seizure incidence according to cholinesterase inhibitor use were analyzed using a multivariable conditional logistic regression model. Results There was no statistically significant association between duration of cholinesterase inhibitors use and seizure risk. Although there was slight increased seizure risk in patient after receiving donepezil for 1 year compared to memantine, subgroup analyses stratified age and sex did not reveal any significant association between cholinesterase inhibitors use and late-onset seizure. Conclusions Our findings suggest no immediate increase in seizure risk is associated with cholinesterase inhibitor use, although the risk of seizure in patients with dementia did increase after one year of continued medication intake. Further study is required to obtain confirmatory results on the seizure-related safety of cognitive enhancers in patients with dementia.https://doi.org/10.1186/s12877-022-03120-5Cholinesterase inhibitorsSeizureDementiaEpilepsyAlzheimer's disease |
| spellingShingle | Junghee Ha Nak-Hoon Son Young Ho Park Eun Lee Eosu Kim Woo Jung Kim Association of cognitive enhancers and incident seizure risk in dementia: a population-based study BMC Geriatrics Cholinesterase inhibitors Seizure Dementia Epilepsy Alzheimer's disease |
| title | Association of cognitive enhancers and incident seizure risk in dementia: a population-based study |
| title_full | Association of cognitive enhancers and incident seizure risk in dementia: a population-based study |
| title_fullStr | Association of cognitive enhancers and incident seizure risk in dementia: a population-based study |
| title_full_unstemmed | Association of cognitive enhancers and incident seizure risk in dementia: a population-based study |
| title_short | Association of cognitive enhancers and incident seizure risk in dementia: a population-based study |
| title_sort | association of cognitive enhancers and incident seizure risk in dementia a population based study |
| topic | Cholinesterase inhibitors Seizure Dementia Epilepsy Alzheimer's disease |
| url | https://doi.org/10.1186/s12877-022-03120-5 |
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