Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures
The rapid identification of pathogens that cause bloodstream infections plays a vital role in the modern clinical microbiology laboratory. Despite demonstrating a significant reduction in turnaround time and a significant effect on clinical decisions, most methods do not provide complete antimicrobi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/11/2/122 |
| _version_ | 1827657611587092480 |
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| author | Felix Roth Nathan D. Leedahl David D. Leedahl Dubert M. Guerrero |
| author_facet | Felix Roth Nathan D. Leedahl David D. Leedahl Dubert M. Guerrero |
| author_sort | Felix Roth |
| collection | DOAJ |
| description | The rapid identification of pathogens that cause bloodstream infections plays a vital role in the modern clinical microbiology laboratory. Despite demonstrating a significant reduction in turnaround time and a significant effect on clinical decisions, most methods do not provide complete antimicrobial susceptibility testing (AST) information. We employed rapid identification (ID) and AST using the Accelerate PhenoTest on positive blood cultures containing Gram-negative bacilli. The length of stay (LOS) significantly decreased from an average of 12.1 days prior to implementation to 6.6 days post-implementation (<i>p</i> = 0.02), representing potential total savings of USD 666,208.00. All-cause mortality did not differ significantly, 27 (19%) versus 18 (12%), <i>p</i> = 0.11. We also observed an associated decrease in the use of broad-spectrum antimicrobials, including meropenem and quinolones. The implementation of a rapid ID and AST method, along with a well-established antimicrobial stewardship program, has the potential to decrease LOS, broad-spectrum antibiotic use, and costs to the healthcare system, with no observable impact on mortality. |
| first_indexed | 2024-03-09T22:47:28Z |
| format | Article |
| id | doaj.art-77f179f427024e61b5d9783bd846e377 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T22:47:28Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-77f179f427024e61b5d9783bd846e3772023-11-23T18:26:47ZengMDPI AGAntibiotics2079-63822022-01-0111212210.3390/antibiotics11020122Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood CulturesFelix Roth0Nathan D. Leedahl1David D. Leedahl2Dubert M. Guerrero3Sanford Health, Fargo, ND 58104, USASanford Health, Fargo, ND 58104, USASanford Health, Fargo, ND 58104, USASanford Health, Fargo, ND 58104, USAThe rapid identification of pathogens that cause bloodstream infections plays a vital role in the modern clinical microbiology laboratory. Despite demonstrating a significant reduction in turnaround time and a significant effect on clinical decisions, most methods do not provide complete antimicrobial susceptibility testing (AST) information. We employed rapid identification (ID) and AST using the Accelerate PhenoTest on positive blood cultures containing Gram-negative bacilli. The length of stay (LOS) significantly decreased from an average of 12.1 days prior to implementation to 6.6 days post-implementation (<i>p</i> = 0.02), representing potential total savings of USD 666,208.00. All-cause mortality did not differ significantly, 27 (19%) versus 18 (12%), <i>p</i> = 0.11. We also observed an associated decrease in the use of broad-spectrum antimicrobials, including meropenem and quinolones. The implementation of a rapid ID and AST method, along with a well-established antimicrobial stewardship program, has the potential to decrease LOS, broad-spectrum antibiotic use, and costs to the healthcare system, with no observable impact on mortality.https://www.mdpi.com/2079-6382/11/2/122antimicrobial susceptibility testingblood culturerapid identification |
| spellingShingle | Felix Roth Nathan D. Leedahl David D. Leedahl Dubert M. Guerrero Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures Antibiotics antimicrobial susceptibility testing blood culture rapid identification |
| title | Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures |
| title_full | Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures |
| title_fullStr | Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures |
| title_full_unstemmed | Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures |
| title_short | Clinical and Financial Impact of Rapid Antimicrobial Susceptibility Testing in Blood Cultures |
| title_sort | clinical and financial impact of rapid antimicrobial susceptibility testing in blood cultures |
| topic | antimicrobial susceptibility testing blood culture rapid identification |
| url | https://www.mdpi.com/2079-6382/11/2/122 |
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