Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate
Abstract A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13659-022-00342-3 |
| _version_ | 1811252186371325952 |
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| author | Shui-Mei Zhang Kun Hu Xiao-Nian Li Han-Dong Sun Pema-Tenzin Puno |
| author_facet | Shui-Mei Zhang Kun Hu Xiao-Nian Li Han-Dong Sun Pema-Tenzin Puno |
| author_sort | Shui-Mei Zhang |
| collection | DOAJ |
| description | Abstract A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculate. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities. Graphical Abstract |
| first_indexed | 2024-04-12T16:31:05Z |
| format | Article |
| id | doaj.art-77f2a19ccf924bf88c7b49a50e2fc9f8 |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-04-12T16:31:05Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-77f2a19ccf924bf88c7b49a50e2fc9f82022-12-22T03:25:08ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092022-05-011211910.1007/s13659-022-00342-3Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculateShui-Mei Zhang0Kun Hu1Xiao-Nian Li2Han-Dong Sun3Pema-Tenzin Puno4State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of SciencesAbstract A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7–13) were isolated from the stems of Schisandra bicolor var. tuberculate. The structures of 1–4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities. Graphical Abstracthttps://doi.org/10.1007/s13659-022-00342-3Schisandra bicolor var. tuberculateCadinane-type sesquiterpenoidsLignansQuantum chemical calculation |
| spellingShingle | Shui-Mei Zhang Kun Hu Xiao-Nian Li Han-Dong Sun Pema-Tenzin Puno Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate Natural Products and Bioprospecting Schisandra bicolor var. tuberculate Cadinane-type sesquiterpenoids Lignans Quantum chemical calculation |
| title | Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate |
| title_full | Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate |
| title_fullStr | Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate |
| title_full_unstemmed | Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate |
| title_short | Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate |
| title_sort | lignans and sesquiterpenoids from the stems of schisandra bicolor var tuberculate |
| topic | Schisandra bicolor var. tuberculate Cadinane-type sesquiterpenoids Lignans Quantum chemical calculation |
| url | https://doi.org/10.1007/s13659-022-00342-3 |
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