Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection
Objective Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. This study aimed to investigate the risk factors of cervical anastomotic leakage and postoperative mortality. Methods In this retrospective, observational study, we recruited 1010 patien...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-09-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605211045540 |
| _version_ | 1818881632928530432 |
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| author | Quanguan Su Chenxi Yin Wei Liao Haoxian Yang Liying Ouyang Rong Yang Gang Ma |
| author_facet | Quanguan Su Chenxi Yin Wei Liao Haoxian Yang Liying Ouyang Rong Yang Gang Ma |
| author_sort | Quanguan Su |
| collection | DOAJ |
| description | Objective Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. This study aimed to investigate the risk factors of cervical anastomotic leakage and postoperative mortality. Methods In this retrospective, observational study, we recruited 1010 patients with esophageal cancer. Cox regression analysis was performed to identify factors affecting anastomotic leakage and postoperative mortality. After propensity score matching, the Kaplan–Meier curve was used to evaluate the effect of leakage on postoperative mortality. Results The number of patients with cervical anastomotic leakage, in-hospital mortality, 30-day postoperative mortality, and 60-day postoperative mortality was 194 (19.2%), 13 (1.3%), 12 (1.2%), and 16 (1.6%), respectively. The total length of hospital stay and hospital stay postoperatively were 29.7 ± 21.1 and 21.3 ± 20.3 days, respectively. Diabetes, stage IV, and an upper thoracic tumor were significant risk factors for leakage. Leakage and diabetes were significant risk factors for postoperative mortality. After propensity score matching, leakage also significantly affected postoperative mortality. Conclusions Patients with tumors in the upper thoracic segment of the esophagus may be more prone to developing anastomotic leakage compared with those with tumors in the middle or lower thoracic segment. Anastomotic leakage may prolong the length of hospital stay and increase postoperative mortality. |
| first_indexed | 2024-12-19T15:04:57Z |
| format | Article |
| id | doaj.art-77f2c4831a6041eeb1057f2ceb355ef3 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-19T15:04:57Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-77f2c4831a6041eeb1057f2ceb355ef32022-12-21T20:16:27ZengSAGE PublishingJournal of International Medical Research1473-23002021-09-014910.1177/03000605211045540Anastomotic leakage and postoperative mortality in patients after esophageal cancer resectionQuanguan SuChenxi YinWei LiaoHaoxian YangLiying OuyangRong YangGang MaObjective Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. This study aimed to investigate the risk factors of cervical anastomotic leakage and postoperative mortality. Methods In this retrospective, observational study, we recruited 1010 patients with esophageal cancer. Cox regression analysis was performed to identify factors affecting anastomotic leakage and postoperative mortality. After propensity score matching, the Kaplan–Meier curve was used to evaluate the effect of leakage on postoperative mortality. Results The number of patients with cervical anastomotic leakage, in-hospital mortality, 30-day postoperative mortality, and 60-day postoperative mortality was 194 (19.2%), 13 (1.3%), 12 (1.2%), and 16 (1.6%), respectively. The total length of hospital stay and hospital stay postoperatively were 29.7 ± 21.1 and 21.3 ± 20.3 days, respectively. Diabetes, stage IV, and an upper thoracic tumor were significant risk factors for leakage. Leakage and diabetes were significant risk factors for postoperative mortality. After propensity score matching, leakage also significantly affected postoperative mortality. Conclusions Patients with tumors in the upper thoracic segment of the esophagus may be more prone to developing anastomotic leakage compared with those with tumors in the middle or lower thoracic segment. Anastomotic leakage may prolong the length of hospital stay and increase postoperative mortality.https://doi.org/10.1177/03000605211045540 |
| spellingShingle | Quanguan Su Chenxi Yin Wei Liao Haoxian Yang Liying Ouyang Rong Yang Gang Ma Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection Journal of International Medical Research |
| title | Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection |
| title_full | Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection |
| title_fullStr | Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection |
| title_full_unstemmed | Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection |
| title_short | Anastomotic leakage and postoperative mortality in patients after esophageal cancer resection |
| title_sort | anastomotic leakage and postoperative mortality in patients after esophageal cancer resection |
| url | https://doi.org/10.1177/03000605211045540 |
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