The changing landscape of automated insulin delivery in the management of type 1 diabetes
Automated insulin delivery systems, also known as closed-loop o r ‘artificial pancreas’ systems, are transforming the management of type 1 diabetes. These systems consist of an algorithm which responds to real-time glucose sensor levels by automatically modulating insulin delivery through an insulin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-08-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/12/8/EC-23-0132.xml |
| _version_ | 1797754726005080064 |
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| author | Rama Lakshman Charlotte Boughton Roman Hovorka |
| author_facet | Rama Lakshman Charlotte Boughton Roman Hovorka |
| author_sort | Rama Lakshman |
| collection | DOAJ |
| description | Automated insulin delivery systems, also known as closed-loop o r ‘artificial pancreas’ systems, are transforming the management of type 1 diabetes. These systems consist of an algorithm which responds to real-time glucose sensor levels by automatically modulating insulin delivery through an insulin pump. We review the rapidly changing landscape of automated insulin-delivery systems over recent decades, from initial prototypes to the different hybrid closed-loop systems commercially available today. We discuss the growing body of clinical trials and real-world evidence demonst rating their glycaemic and psychosocial benefits. We also address future directions in auto mated insulin delivery such as dual-hormone systems and adjunct therapy as well as the chal lenges around ensuring equitable access to closed-loop technology. |
| first_indexed | 2024-03-12T17:36:47Z |
| format | Article |
| id | doaj.art-77f2d94d97d44107b5f4dc05aae310d7 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-03-12T17:36:47Z |
| publishDate | 2023-08-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-77f2d94d97d44107b5f4dc05aae310d72023-08-04T09:53:34ZengBioscientificaEndocrine Connections2049-36142023-08-01128113https://doi.org/10.1530/EC-23-0132The changing landscape of automated insulin delivery in the management of type 1 diabetesRama Lakshman0Charlotte Boughton1Roman Hovorka2Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKWellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK; Cambridge University Hospitals NHS Foundation Trust, Wolfson Diabetes and Endocrine Clinic, Cambridge, UK Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UKAutomated insulin delivery systems, also known as closed-loop o r ‘artificial pancreas’ systems, are transforming the management of type 1 diabetes. These systems consist of an algorithm which responds to real-time glucose sensor levels by automatically modulating insulin delivery through an insulin pump. We review the rapidly changing landscape of automated insulin-delivery systems over recent decades, from initial prototypes to the different hybrid closed-loop systems commercially available today. We discuss the growing body of clinical trials and real-world evidence demonst rating their glycaemic and psychosocial benefits. We also address future directions in auto mated insulin delivery such as dual-hormone systems and adjunct therapy as well as the chal lenges around ensuring equitable access to closed-loop technology.https://ec.bioscientifica.com/view/journals/ec/12/8/EC-23-0132.xmlautomated insulin deliveryartificial pancreasclosed-loop systemstype 1 diabetes |
| spellingShingle | Rama Lakshman Charlotte Boughton Roman Hovorka The changing landscape of automated insulin delivery in the management of type 1 diabetes Endocrine Connections automated insulin delivery artificial pancreas closed-loop systems type 1 diabetes |
| title | The changing landscape of automated insulin delivery in the management of type 1 diabetes |
| title_full | The changing landscape of automated insulin delivery in the management of type 1 diabetes |
| title_fullStr | The changing landscape of automated insulin delivery in the management of type 1 diabetes |
| title_full_unstemmed | The changing landscape of automated insulin delivery in the management of type 1 diabetes |
| title_short | The changing landscape of automated insulin delivery in the management of type 1 diabetes |
| title_sort | changing landscape of automated insulin delivery in the management of type 1 diabetes |
| topic | automated insulin delivery artificial pancreas closed-loop systems type 1 diabetes |
| url | https://ec.bioscientifica.com/view/journals/ec/12/8/EC-23-0132.xml |
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