Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy
Changes in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiological...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Saratov State Medical University
2014-03-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/2014_01-01_199-203.pdf |
| _version_ | 1818789703346814976 |
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| author | Reshetko O.V. Lutsevich К.А. |
| author_facet | Reshetko O.V. Lutsevich К.А. |
| author_sort | Reshetko O.V. |
| collection | DOAJ |
| description | Changes in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiologically-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and serves in predicting drug exposure and response at the personal level. |
| first_indexed | 2024-12-18T14:43:47Z |
| format | Article |
| id | doaj.art-77f321c2415147c6816e8f1f26764eef |
| institution | Directory Open Access Journal |
| issn | 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-18T14:43:47Z |
| publishDate | 2014-03-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-77f321c2415147c6816e8f1f26764eef2022-12-21T21:04:19ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал2076-25182014-03-011011992033655Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancyReshetko O.V.0Lutsevich К.А.1Saratov State Medical UniversitySaratov State Medical UniversityChanges in maternal physiology and metabolic during pregnancy influence pharmacokinetics and illustrate that standard adult dosing is likely to be incorrect during pregnancy. Different pharmacometric approaches are available for design and analysis of clinical studies during pregnancy. Physiologically-based pharmacokinetic (PBPK) model could be used to evaluate different dosing regimens for pregnant women and serves in predicting drug exposure and response at the personal level.http://www.ssmj.ru/system/files/2014_01-01_199-203.pdfpharmacometricpharmakokineticspregnancy |
| spellingShingle | Reshetko O.V. Lutsevich К.А. Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy Саратовский научно-медицинский журнал pharmacometric pharmakokinetics pregnancy |
| title | Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy |
| title_full | Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy |
| title_fullStr | Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy |
| title_full_unstemmed | Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy |
| title_short | Pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy |
| title_sort | pharmacometrics as an instrument of clinical pharmacology for optimization of drugs dosing regimens during pregnancy |
| topic | pharmacometric pharmakokinetics pregnancy |
| url | http://www.ssmj.ru/system/files/2014_01-01_199-203.pdf |
| work_keys_str_mv | AT reshetkoov pharmacometricsasaninstrumentofclinicalpharmacologyforoptimizationofdrugsdosingregimensduringpregnancy AT lutsevichka pharmacometricsasaninstrumentofclinicalpharmacologyforoptimizationofdrugsdosingregimensduringpregnancy |