Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study
PurposeThis study evaluated the association between metabolic health status and incident kidney cancer among obese participants.Materials and methodsA total of 514,866 individuals were included from the Korean National Health Insurance Service-National Health Screening Cohort. Changes in metabolic h...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.976056/full |
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| author | Yun Kyung Cho Hwi Seung Kim Hwi Seung Kim Joong-Yeol Park Joong-Yeol Park Woo Je Lee Woo Je Lee Ye-Jee Kim Chang Hee Jung Chang Hee Jung |
| author_facet | Yun Kyung Cho Hwi Seung Kim Hwi Seung Kim Joong-Yeol Park Joong-Yeol Park Woo Je Lee Woo Je Lee Ye-Jee Kim Chang Hee Jung Chang Hee Jung |
| author_sort | Yun Kyung Cho |
| collection | DOAJ |
| description | PurposeThis study evaluated the association between metabolic health status and incident kidney cancer among obese participants.Materials and methodsA total of 514,866 individuals were included from the Korean National Health Insurance Service-National Health Screening Cohort. Changes in metabolic health status and obesity from the baseline examination in 2009–2010 to the next biannual examination in 2011–2012 were determined. Based on the status change, obese participants were divided into four groups: stable metabolically healthy obesity, metabolically healthy obesity to metabolically unhealthy obesity, metabolically unhealthy obesity to metabolically healthy obesity, and stable metabolically unhealthy obesity.ResultsThe stable metabolically healthy obesity phenotype did not confer an increased risk of incident kidney cancer, compared to the stable metabolically healthy non-obese group. In contrast, the metabolically healthy obesity to metabolically unhealthy obesity group had a significantly higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. Among patients with metabolically unhealthy obesity at baseline, those who transitioned to the metabolically healthy obese group had no increased risk of kidney cancer, whereas those who remained in metabolically unhealthy obesity status had a higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. The transition or maintenance of metabolic health was a decisive factor for kidney cancer in obese patients.ConclusionsMaintaining or restoring metabolic health should be stressed upon in obese patients to reduce the risk of kidney cancer. |
| first_indexed | 2024-04-12T16:30:08Z |
| format | Article |
| id | doaj.art-77f6d82b4fca42f1b54b0fe4d5ad538e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T16:30:08Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-77f6d82b4fca42f1b54b0fe4d5ad538e2022-12-22T03:25:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.976056976056Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort studyYun Kyung Cho0Hwi Seung Kim1Hwi Seung Kim2Joong-Yeol Park3Joong-Yeol Park4Woo Je Lee5Woo Je Lee6Ye-Jee Kim7Chang Hee Jung8Chang Hee Jung9Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South KoreaDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaDepartment of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaAsan Diabetes Center, Asan Medical Center, Seoul, South KoreaPurposeThis study evaluated the association between metabolic health status and incident kidney cancer among obese participants.Materials and methodsA total of 514,866 individuals were included from the Korean National Health Insurance Service-National Health Screening Cohort. Changes in metabolic health status and obesity from the baseline examination in 2009–2010 to the next biannual examination in 2011–2012 were determined. Based on the status change, obese participants were divided into four groups: stable metabolically healthy obesity, metabolically healthy obesity to metabolically unhealthy obesity, metabolically unhealthy obesity to metabolically healthy obesity, and stable metabolically unhealthy obesity.ResultsThe stable metabolically healthy obesity phenotype did not confer an increased risk of incident kidney cancer, compared to the stable metabolically healthy non-obese group. In contrast, the metabolically healthy obesity to metabolically unhealthy obesity group had a significantly higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. Among patients with metabolically unhealthy obesity at baseline, those who transitioned to the metabolically healthy obese group had no increased risk of kidney cancer, whereas those who remained in metabolically unhealthy obesity status had a higher risk of incident kidney cancer than the stable metabolically healthy non-obese group. The transition or maintenance of metabolic health was a decisive factor for kidney cancer in obese patients.ConclusionsMaintaining or restoring metabolic health should be stressed upon in obese patients to reduce the risk of kidney cancer.https://www.frontiersin.org/articles/10.3389/fendo.2022.976056/fullkidney cancermetabolic syndromeobesitypopulation-based cohort studyphenotypic change |
| spellingShingle | Yun Kyung Cho Hwi Seung Kim Hwi Seung Kim Joong-Yeol Park Joong-Yeol Park Woo Je Lee Woo Je Lee Ye-Jee Kim Chang Hee Jung Chang Hee Jung Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study Frontiers in Endocrinology kidney cancer metabolic syndrome obesity population-based cohort study phenotypic change |
| title | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
| title_full | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
| title_fullStr | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
| title_full_unstemmed | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
| title_short | Implications of metabolic health status and obesity on the risk of kidney cancer: A nationwide population-based cohort study |
| title_sort | implications of metabolic health status and obesity on the risk of kidney cancer a nationwide population based cohort study |
| topic | kidney cancer metabolic syndrome obesity population-based cohort study phenotypic change |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.976056/full |
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