Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization
Background: Macular neovascularization (MNV) has been evaluated by optical coherence tomography (OCT) imaging using various approaches. However, few studies have examined their differences. This study analyzed type 1 MNV with a combination of two approaches: scale bar and binarization. Methods: We e...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1383 |
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| author | Hiromasa Hirai Mariko Yamashita Nobuo Ijuin Hironobu Jimura Tomo Nishi Nahoko Ogata Tetsuo Ueda |
| author_facet | Hiromasa Hirai Mariko Yamashita Nobuo Ijuin Hironobu Jimura Tomo Nishi Nahoko Ogata Tetsuo Ueda |
| author_sort | Hiromasa Hirai |
| collection | DOAJ |
| description | Background: Macular neovascularization (MNV) has been evaluated by optical coherence tomography (OCT) imaging using various approaches. However, few studies have examined their differences. This study analyzed type 1 MNV with a combination of two approaches: scale bar and binarization. Methods: We enrolled 84 patients with untreated type 1 MNV. We measured choroidal parameters using a scale bar and defined the ratios of superficial choroidal thickness to choroidal vessel diameter (SV ratios). We also used binarization and calculated the ratios of the luminal to the choroidal area (LC ratios) in two directions (horizontal and vertical). Results: Fifty-one patients (61%) were classified as having polyps. SV ratios in the group with polyps were significantly lower than in the group without (<i>p</i> < 0.001). The receiver operating characteristic (ROC) curve showed that the SV ratio was predictive of polyps (AUC 0.733, 95% CI: 0.621–0.844). In patients without polyps, horizontal LC ratios were significantly higher in a subgroup with subretinal fluid than in those without (<i>p</i> = 0.047). The ROC curve showed that the LC ratio was predictive of subretinal fluid (AUC 0.722, 95% CI: 0.517–0.926). Conclusion: The SV ratio reflects the MNV disease type, whereas the LC ratio reflects MNV disease activity. Establishing cut-off values for each ratio may be useful for MNV diagnosis. |
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| language | English |
| last_indexed | 2024-04-25T00:26:40Z |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-77f7072403414f728f56b83a0165836b2024-03-12T16:48:15ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135138310.3390/jcm13051383Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and BinarizationHiromasa Hirai0Mariko Yamashita1Nobuo Ijuin2Hironobu Jimura3Tomo Nishi4Nahoko Ogata5Tetsuo Ueda6Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, JapanDepartment of Ophthalmology, Nara Prefecture Seiwa Medical Center, 1-14-16 Mimuro, Sango 636-0802, JapanDepartment of Ophthalmology, Nara City Hospital, 1-50-1 Higashikidera-cho, Nara 630-8305, JapanDepartment of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, JapanDepartment of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, JapanDepartment of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, JapanDepartment of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, JapanBackground: Macular neovascularization (MNV) has been evaluated by optical coherence tomography (OCT) imaging using various approaches. However, few studies have examined their differences. This study analyzed type 1 MNV with a combination of two approaches: scale bar and binarization. Methods: We enrolled 84 patients with untreated type 1 MNV. We measured choroidal parameters using a scale bar and defined the ratios of superficial choroidal thickness to choroidal vessel diameter (SV ratios). We also used binarization and calculated the ratios of the luminal to the choroidal area (LC ratios) in two directions (horizontal and vertical). Results: Fifty-one patients (61%) were classified as having polyps. SV ratios in the group with polyps were significantly lower than in the group without (<i>p</i> < 0.001). The receiver operating characteristic (ROC) curve showed that the SV ratio was predictive of polyps (AUC 0.733, 95% CI: 0.621–0.844). In patients without polyps, horizontal LC ratios were significantly higher in a subgroup with subretinal fluid than in those without (<i>p</i> = 0.047). The ROC curve showed that the LC ratio was predictive of subretinal fluid (AUC 0.722, 95% CI: 0.517–0.926). Conclusion: The SV ratio reflects the MNV disease type, whereas the LC ratio reflects MNV disease activity. Establishing cut-off values for each ratio may be useful for MNV diagnosis.https://www.mdpi.com/2077-0383/13/5/1383age-related macular degenerationchoroidal neovascularizationmacular neovascularizationbinarizationthe ratio of the luminal to the choroidal areachoroidal vascularity index |
| spellingShingle | Hiromasa Hirai Mariko Yamashita Nobuo Ijuin Hironobu Jimura Tomo Nishi Nahoko Ogata Tetsuo Ueda Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization Journal of Clinical Medicine age-related macular degeneration choroidal neovascularization macular neovascularization binarization the ratio of the luminal to the choroidal area choroidal vascularity index |
| title | Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization |
| title_full | Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization |
| title_fullStr | Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization |
| title_full_unstemmed | Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization |
| title_short | Evaluation of Choroidal Structure in Type 1 Macular Neovascularization Using Different Optical Coherence Tomography Analyses: Scale Bar and Binarization |
| title_sort | evaluation of choroidal structure in type 1 macular neovascularization using different optical coherence tomography analyses scale bar and binarization |
| topic | age-related macular degeneration choroidal neovascularization macular neovascularization binarization the ratio of the luminal to the choroidal area choroidal vascularity index |
| url | https://www.mdpi.com/2077-0383/13/5/1383 |
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