Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database
ABSTRACT Objective: To calculate the rate of tuberculosis recurrence, estimate its average time until recurrence, and identify factors associated with recurrence in Brazil. Methods: Retrospective cohort study with a linked database from the Notifiable Diseases Information System. The study include...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Pós-Graduação em Saúde Coletiva
2024-04-01
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| Series: | Revista Brasileira de Epidemiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2024000100414&lng=en&tlng=en |
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| author | Daniele Maria Pelissari Lucas Vinícius de Lima Gabriel Pavinati Gabriela Tavares Magnabosco José Nildo de Barros Silva Júnior Patricia Bartholomay Fernanda Dockhorn Costa Johansen |
| author_facet | Daniele Maria Pelissari Lucas Vinícius de Lima Gabriel Pavinati Gabriela Tavares Magnabosco José Nildo de Barros Silva Júnior Patricia Bartholomay Fernanda Dockhorn Costa Johansen |
| author_sort | Daniele Maria Pelissari |
| collection | DOAJ |
| description | ABSTRACT Objective: To calculate the rate of tuberculosis recurrence, estimate its average time until recurrence, and identify factors associated with recurrence in Brazil. Methods: Retrospective cohort study with a linked database from the Notifiable Diseases Information System. The study included individuals diagnosed with tuberculosis in 2015, focusing on those who experienced their first recurrence within 6.5 years. We estimated the relative risk (RR) and its 95% confidence interval (95%CI), as well as the population attributable fraction (PAF) or the population preventable fraction (PPF) of associated factors. Results: Within a 6.5-year period, 3,253 individuals (6.5%) experienced tuberculosis recurrence, with a median time of 2.2 years. Positively associated factors included: male sex (RR: 1.4; 95%CI 1.3–1.5; PAF: 22.9%), age 30 to 59 years (RR: 3.0; 95%CI 1.6–5.7; PAF: 36.0%), black race (RR: 1.3; 95%CI 1.2–1.5; PAF: 3.5%), mixed race (RR: 1.3; 95%CI 1.2–1.4; PAF: 10.6%), deprivation of liberty (RR: 1.9; 95%CI 1.7–2.1; PAF: 9.1%), pulmonary/mixed clinical form (RR: 1.7; 95%CI 1.4–1.9; PAF: 37.1%), acquired immunodeficiency syndrome diagnosis (RR: 1.8; 95%CI 1.5–1.9; PAF: 4.3%), and alcohol use (RR: 1.2; 95%CI 1.1–1.3; PAF: 2.9%). Negatively associated factors were: 12 or more years of schooling (RR: 0.5; 95%CI 0.4–0.6; PPF: 3.3%) and supervised treatment (RR: 0.9; 95%CI 0.8–0.9; PPF: 4.4%). Conclusion: This study revealed high tuberculosis recurrence rates in Brazil, influenced by sociodemographic, compartmental, and social factors, both positively and negatively impacting disease recurrence. |
| first_indexed | 2024-04-24T06:01:02Z |
| format | Article |
| id | doaj.art-77faf325daa241eca76852ab3a8add29 |
| institution | Directory Open Access Journal |
| issn | 1980-5497 |
| language | English |
| last_indexed | 2024-04-24T06:01:02Z |
| publishDate | 2024-04-01 |
| publisher | Associação Brasileira de Pós-Graduação em Saúde Coletiva |
| record_format | Article |
| series | Revista Brasileira de Epidemiologia |
| spelling | doaj.art-77faf325daa241eca76852ab3a8add292024-04-23T07:37:23ZengAssociação Brasileira de Pós-Graduação em Saúde ColetivaRevista Brasileira de Epidemiologia1980-54972024-04-012710.1590/1980-549720240016Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked databaseDaniele Maria Pelissarihttps://orcid.org/0000-0002-0760-1875Lucas Vinícius de Limahttps://orcid.org/0000-0002-9582-9641Gabriel Pavinatihttps://orcid.org/0000-0002-0289-8219Gabriela Tavares Magnaboscohttps://orcid.org/0000-0003-3318-6748José Nildo de Barros Silva Júniorhttps://orcid.org/0000-0001-9958-8462Patricia Bartholomayhttps://orcid.org/0000-0002-4881-0630Fernanda Dockhorn Costa Johansenhttps://orcid.org/0000-0002-1762-9484ABSTRACT Objective: To calculate the rate of tuberculosis recurrence, estimate its average time until recurrence, and identify factors associated with recurrence in Brazil. Methods: Retrospective cohort study with a linked database from the Notifiable Diseases Information System. The study included individuals diagnosed with tuberculosis in 2015, focusing on those who experienced their first recurrence within 6.5 years. We estimated the relative risk (RR) and its 95% confidence interval (95%CI), as well as the population attributable fraction (PAF) or the population preventable fraction (PPF) of associated factors. Results: Within a 6.5-year period, 3,253 individuals (6.5%) experienced tuberculosis recurrence, with a median time of 2.2 years. Positively associated factors included: male sex (RR: 1.4; 95%CI 1.3–1.5; PAF: 22.9%), age 30 to 59 years (RR: 3.0; 95%CI 1.6–5.7; PAF: 36.0%), black race (RR: 1.3; 95%CI 1.2–1.5; PAF: 3.5%), mixed race (RR: 1.3; 95%CI 1.2–1.4; PAF: 10.6%), deprivation of liberty (RR: 1.9; 95%CI 1.7–2.1; PAF: 9.1%), pulmonary/mixed clinical form (RR: 1.7; 95%CI 1.4–1.9; PAF: 37.1%), acquired immunodeficiency syndrome diagnosis (RR: 1.8; 95%CI 1.5–1.9; PAF: 4.3%), and alcohol use (RR: 1.2; 95%CI 1.1–1.3; PAF: 2.9%). Negatively associated factors were: 12 or more years of schooling (RR: 0.5; 95%CI 0.4–0.6; PPF: 3.3%) and supervised treatment (RR: 0.9; 95%CI 0.8–0.9; PPF: 4.4%). Conclusion: This study revealed high tuberculosis recurrence rates in Brazil, influenced by sociodemographic, compartmental, and social factors, both positively and negatively impacting disease recurrence.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2024000100414&lng=en&tlng=enTuberculosisRecurrenceCohort studiesRegression analysisRisk factorsProtective factors |
| spellingShingle | Daniele Maria Pelissari Lucas Vinícius de Lima Gabriel Pavinati Gabriela Tavares Magnabosco José Nildo de Barros Silva Júnior Patricia Bartholomay Fernanda Dockhorn Costa Johansen Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database Revista Brasileira de Epidemiologia Tuberculosis Recurrence Cohort studies Regression analysis Risk factors Protective factors |
| title | Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database |
| title_full | Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database |
| title_fullStr | Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database |
| title_full_unstemmed | Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database |
| title_short | Time until tuberculosis recurrence and associated factors in Brazil: a populationbased retrospective cohort study using a linked database |
| title_sort | time until tuberculosis recurrence and associated factors in brazil a populationbased retrospective cohort study using a linked database |
| topic | Tuberculosis Recurrence Cohort studies Regression analysis Risk factors Protective factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2024000100414&lng=en&tlng=en |
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